000129614 001__ 129614
000129614 005__ 20240109134256.0
000129614 0247_ $$2doi$$a10.1021/acs.inorgchem.8b01464
000129614 0248_ $$2sideral$$a108025
000129614 037__ $$aART-2018-108025
000129614 041__ $$aeng
000129614 100__ $$aQuero, J.
000129614 245__ $$aProteasome versus Thioredoxin Reductase Competition as Possible Biological Targets in Antitumor Mixed Thiolate-Dithiocarbamate Gold(III) Complexes
000129614 260__ $$c2018
000129614 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129614 5203_ $$aNew mixed gold(III) derivatives with dithiocarbamate and thiolate ligands have been synthesized and characterized. They display high anticancer activity against colon cancer cell lines without affecting to differentiated enterocytes, high stability in phosphate-buffered saline solution, and resistance to gold reduction in the presence of reducing agents in the majority of the derivatives. Some of them show interaction with thioredoxin reductase as derived from in vitro analysis and computational studies. However, a competition between this enzyme and proteasome is detected in cells, which is corroborated by the determination of proteasomal chymotrypsin-like activity inhibition. In addition, some of these dithiocarbamate gold(III) derivatives reduce cell viability and proliferation by intrinsic apoptotic pathway, with changes in mitochondrial membrane potential, cytochrome c release and caspase-3 activation. Consequently, our results show new complexes with proteasome as possible target in colorectal cancer.
000129614 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A32$$9info:eu-repo/grantAgreement/ES/DGA/E104$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75441-R
000129614 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000129614 590__ $$a4.85$$b2018
000129614 591__ $$aCHEMISTRY, INORGANIC & NUCLEAR$$b4 / 45 = 0.089$$c2018$$dQ1$$eT1
000129614 592__ $$a1.501$$b2018
000129614 593__ $$aChemistry (miscellaneous)$$c2018$$dQ1
000129614 593__ $$aPhysical and Theoretical Chemistry$$c2018$$dQ1
000129614 593__ $$aInorganic Chemistry$$c2018$$dQ1
000129614 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000129614 700__ $$aCabello, S.
000129614 700__ $$aFuertes, T.
000129614 700__ $$aMármol, I.
000129614 700__ $$aLaplaza, R.
000129614 700__ $$aPolo, V.
000129614 700__ $$0(orcid)0000-0003-0553-0695$$aConcepción Gimeno, M.$$uUniversidad de Zaragoza
000129614 700__ $$0(orcid)0000-0002-3595-7668$$aRodriguez-Yoldi, M.J.$$uUniversidad de Zaragoza
000129614 700__ $$0(orcid)0000-0003-2457-3674$$aCerrada, E.$$uUniversidad de Zaragoza
000129614 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000129614 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000129614 773__ $$g57, 17 (2018), 10832-10845$$pInorg. chem.$$tInorganic Chemistry$$x0020-1669
000129614 8564_ $$s830762$$uhttps://zaguan.unizar.es/record/129614/files/texto_completo.pdf$$yPostprint
000129614 8564_ $$s2814247$$uhttps://zaguan.unizar.es/record/129614/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000129614 909CO $$ooai:zaguan.unizar.es:129614$$particulos$$pdriver
000129614 951__ $$a2024-01-09-13:33:08
000129614 980__ $$aARTICLE