129614 20240109134256.0 doi 10.1021/acs.inorgchem.8b01464 sideral 108025 ART-2018-108025 eng Quero, J. Proteasome versus Thioredoxin Reductase Competition as Possible Biological Targets in Antitumor Mixed Thiolate-Dithiocarbamate Gold(III) Complexes 2018 Access copy available to the general public Unrestricted New mixed gold(III) derivatives with dithiocarbamate and thiolate ligands have been synthesized and characterized. They display high anticancer activity against colon cancer cell lines without affecting to differentiated enterocytes, high stability in phosphate-buffered saline solution, and resistance to gold reduction in the presence of reducing agents in the majority of the derivatives. Some of them show interaction with thioredoxin reductase as derived from in vitro analysis and computational studies. However, a competition between this enzyme and proteasome is detected in cells, which is corroborated by the determination of proteasomal chymotrypsin-like activity inhibition. In addition, some of these dithiocarbamate gold(III) derivatives reduce cell viability and proliferation by intrinsic apoptotic pathway, with changes in mitochondrial membrane potential, cytochrome c release and caspase-3 activation. Consequently, our results show new complexes with proteasome as possible target in colorectal cancer. info:eu-repo/grantAgreement/ES/DGA/A32 info:eu-repo/grantAgreement/ES/DGA/E104 info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75441-R info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.85 2018 CHEMISTRY, INORGANIC & NUCLEAR 4 / 45 = 0.089 2018 Q1 T1 1.501 2018 Chemistry (miscellaneous) 2018 Q1 Physical and Theoretical Chemistry 2018 Q1 Inorganic Chemistry 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Cabello, S. Fuertes, T. Mármol, I. Laplaza, R. Polo, V. Concepción Gimeno, M. Universidad de Zaragoza (orcid)0000-0003-0553-0695 Rodriguez-Yoldi, M.J. Universidad de Zaragoza (orcid)0000-0002-3595-7668 Cerrada, E. Universidad de Zaragoza (orcid)0000-0003-2457-3674 2010 760 Universidad de Zaragoza Dpto. Química Inorgánica Área Química Inorgánica 1005 410 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Fisiología 57, 17 (2018), 10832-10845 Inorg. chem. Inorganic Chemistry 0020-1669 830762 http://zaguan.unizar.es/record/129614/files/texto_completo.pdf Postprint 2814247 http://zaguan.unizar.es/record/129614/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:129614 articulos driver 2024-01-09-13:33:08 ARTICLE