000129658 001__ 129658
000129658 005__ 20240731103327.0
000129658 0247_ $$2doi$$a10.3390/genes14101941
000129658 0248_ $$2sideral$$a135872
000129658 037__ $$aART-2023-135872
000129658 041__ $$aeng
000129658 100__ $$aHervás-Rivero, Carlos$$uUniversidad de Zaragoza
000129658 245__ $$aGenomic scanning of inbreeding depression for litter size in two varieties of iberian pigs
000129658 260__ $$c2023
000129658 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129658 5203_ $$aInbreeding depression is expected to be more pronounced in fitness-related traits, such as pig litter size. Recent studies have suggested that the genetic determinism of inbreeding depression may be heterogeneous across the genome. Therefore, the objective of this study was to conduct a genomic scan of the whole pig autosomal genome to detect the genomic regions that control inbreeding depression for litter size in two varieties of Iberian pigs (Entrepelado and Retinto). The datasets consisted of 2069 (338 sows) and 2028 (327 sows) records of litter size (Total Number Born and Number Born Alive) for the Entrepelado and Retinto varieties. All sows were genotyped using the Geneseek GGP PorcineHD 70 K chip. We employed the Unfavorable Haplotype Finder software to extract runs of homozygosity (ROHs) and conducted a mixed-model analysis to identify highly significant differences between homozygous and heterozygous sows for each specific ROH. A total of eight genomic regions located on SSC2, SSC5, SSC7, SSC8, and SSC13 were significantly associated with inbreeding depression, housing some relevant genes such as FSHR, LHCGR, CORIN, AQP6, and CEP120.
000129658 536__ $$9info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-114705RB-I00
000129658 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000129658 590__ $$a2.8$$b2023
000129658 592__ $$a0.817$$b2023
000129658 591__ $$aGENETICS & HEREDITY$$b85 / 191 = 0.445$$c2023$$dQ2$$eT2
000129658 593__ $$aGenetics$$c2023$$dQ2
000129658 593__ $$aGenetics (clinical)$$c2023$$dQ3
000129658 594__ $$a5.2$$b2023
000129658 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000129658 700__ $$aSrihi, Houssemeddine$$uUniversidad de Zaragoza
000129658 700__ $$aLópez-Carbonell, David$$uUniversidad de Zaragoza
000129658 700__ $$aCasellas, Joaquim
000129658 700__ $$aIbáñez-Escriche, Noelia
000129658 700__ $$aNegro, Sara
000129658 700__ $$0(orcid)0000-0001-6256-5478$$aVarona, Luis$$uUniversidad de Zaragoza
000129658 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000129658 773__ $$g14, 10 (2023), 1941 [11 pp.]$$pGenes (Basel)$$tGenes$$x2073-4425
000129658 8564_ $$s2857690$$uhttps://zaguan.unizar.es/record/129658/files/texto_completo.pdf$$yVersión publicada
000129658 8564_ $$s2602957$$uhttps://zaguan.unizar.es/record/129658/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000129658 909CO $$ooai:zaguan.unizar.es:129658$$particulos$$pdriver
000129658 951__ $$a2024-07-31-09:45:10
000129658 980__ $$aARTICLE