129658 20241125101134.0 doi 10.3390/genes14101941 sideral 135872 ART-2023-135872 eng Hervás-Rivero, Carlos Universidad de Zaragoza Genomic scanning of inbreeding depression for litter size in two varieties of iberian pigs 2023 Access copy available to the general public Unrestricted Inbreeding depression is expected to be more pronounced in fitness-related traits, such as pig litter size. Recent studies have suggested that the genetic determinism of inbreeding depression may be heterogeneous across the genome. Therefore, the objective of this study was to conduct a genomic scan of the whole pig autosomal genome to detect the genomic regions that control inbreeding depression for litter size in two varieties of Iberian pigs (Entrepelado and Retinto). The datasets consisted of 2069 (338 sows) and 2028 (327 sows) records of litter size (Total Number Born and Number Born Alive) for the Entrepelado and Retinto varieties. All sows were genotyped using the Geneseek GGP PorcineHD 70 K chip. We employed the Unfavorable Haplotype Finder software to extract runs of homozygosity (ROHs) and conducted a mixed-model analysis to identify highly significant differences between homozygous and heterozygous sows for each specific ROH. A total of eight genomic regions located on SSC2, SSC5, SSC7, SSC8, and SSC13 were significantly associated with inbreeding depression, housing some relevant genes such as FSHR, LHCGR, CORIN, AQP6, and CEP120. info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent info:eu-repo/grantAgreement/ES/MICINN/PID2020-114705RB-I00 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 2.8 2023 GENETICS & HEREDITY 85 / 191 = 0.445 2023 Q2 T2 0.817 2023 Genetics 2023 Q2 Genetics (clinical) 2023 Q3 5.2 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Srihi, Houssemeddine Universidad de Zaragoza López-Carbonell, David Universidad de Zaragoza Casellas, Joaquim Ibáñez-Escriche, Noelia Negro, Sara Varona, Luis Universidad de Zaragoza (orcid)0000-0001-6256-5478 1001 420 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Genética 14, 10 (2023), 1941 [11 pp.] Genes (Basel) Genes 2073-4425 2857690 http://zaguan.unizar.es/record/129658/files/texto_completo.pdf Versión publicada 2602957 http://zaguan.unizar.es/record/129658/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:129658 articulos driver 2024-11-22-11:59:59 ARTICLE