000129679 001__ 129679
000129679 005__ 20251113150203.0
000129679 0247_ $$2doi$$a10.1109/TPEL.2023.3240244
000129679 0248_ $$2sideral$$a133110
000129679 037__ $$aART-2023-133110
000129679 041__ $$aeng
000129679 100__ $$0(orcid)0000-0001-8399-4650$$aSarnago, H.$$uUniversidad de Zaragoza
000129679 245__ $$aElectroporation pulse generator for biomedical applications with improved output voltage ripple and reduced bus capacitor
000129679 260__ $$c2023
000129679 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129679 5203_ $$aElectroporation is a promising cancer treatment based on applying short electric field pulses. In this context, highly versatile pulse generators are required to generate high-voltage low-ripple pulses in the µs range. In the past, several multi-level converters have been proposed to achieve this aim. Achieving constant output voltage and, consequently, electric field is essential to obtain predictable treatments and minimize the risks of tumor relapse. However, significant bus capacitance is required to achieve the required performance, leading to bulky equipment with serious safety implications due to the stored energy. In this letter, a high-performance pulse generator for electroporation is proposed that takes advantage of a multi-level structure with linear voltage regulation to achieve the desired performance with reduced bus capacitance. The proposed converter has been designed and tested experimentally during both laboratory and operation room treatments.
000129679 536__ $$9info:eu-repo/grantAgreement/EUR/AEI/TED2021-129274B-I00$$9info:eu-repo/grantAgreement/ES/ISCIII/PI21-00440$$9info:eu-repo/grantAgreement/ES/MICINN-AEI/PDC2021-120898-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-103939RB-I00
000129679 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000129679 590__ $$a6.6$$b2023
000129679 592__ $$a3.644$$b2023
000129679 591__ $$aENGINEERING, ELECTRICAL & ELECTRONIC$$b39 / 353 = 0.11$$c2023$$dQ1$$eT1
000129679 593__ $$aElectrical and Electronic Engineering$$c2023$$dQ1
000129679 594__ $$a15.2$$b2023
000129679 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000129679 700__ $$0(orcid)0000-0002-9655-5531$$aBurdio, J. M.$$uUniversidad de Zaragoza
000129679 700__ $$0(orcid)0000-0002-1284-9007$$aLucia, Ó.$$uUniversidad de Zaragoza
000129679 7102_ $$15008$$2785$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Tecnología Electrónica
000129679 773__ $$g38, 6 (2023), 6774-6778$$pIEEE trans. power electron.$$tIEEE Transactions on Power Electronics$$x0885-8993
000129679 8564_ $$s1188490$$uhttps://zaguan.unizar.es/record/129679/files/texto_completo.pdf$$yPostprint
000129679 8564_ $$s3003317$$uhttps://zaguan.unizar.es/record/129679/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000129679 909CO $$ooai:zaguan.unizar.es:129679$$particulos$$pdriver
000129679 951__ $$a2025-11-13-15:00:44
000129679 980__ $$aARTICLE