129679 20251113150203.0 doi 10.1109/TPEL.2023.3240244 sideral 133110 ART-2023-133110 eng Sarnago, H. Universidad de Zaragoza (orcid)0000-0001-8399-4650 Electroporation pulse generator for biomedical applications with improved output voltage ripple and reduced bus capacitor 2023 Access copy available to the general public Unrestricted Electroporation is a promising cancer treatment based on applying short electric field pulses. In this context, highly versatile pulse generators are required to generate high-voltage low-ripple pulses in the µs range. In the past, several multi-level converters have been proposed to achieve this aim. Achieving constant output voltage and, consequently, electric field is essential to obtain predictable treatments and minimize the risks of tumor relapse. However, significant bus capacitance is required to achieve the required performance, leading to bulky equipment with serious safety implications due to the stored energy. In this letter, a high-performance pulse generator for electroporation is proposed that takes advantage of a multi-level structure with linear voltage regulation to achieve the desired performance with reduced bus capacitance. The proposed converter has been designed and tested experimentally during both laboratory and operation room treatments. info:eu-repo/grantAgreement/EUR/AEI/TED2021-129274B-I00 info:eu-repo/grantAgreement/ES/ISCIII/PI21-00440 info:eu-repo/grantAgreement/ES/MICINN-AEI/PDC2021-120898-I00 info:eu-repo/grantAgreement/ES/MICINN/PID2019-103939RB-I00 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 6.6 2023 ENGINEERING, ELECTRICAL & ELECTRONIC 39 / 353 = 0.11 2023 Q1 T1 3.644 2023 Electrical and Electronic Engineering 2023 Q1 15.2 2023 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Burdio, J. M. Universidad de Zaragoza (orcid)0000-0002-9655-5531 Lucia, Ó. Universidad de Zaragoza (orcid)0000-0002-1284-9007 5008 785 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Tecnología Electrónica 38, 6 (2023), 6774-6778 IEEE trans. power electron. IEEE Transactions on Power Electronics 0885-8993 1188490 http://zaguan.unizar.es/record/129679/files/texto_completo.pdf Postprint 3003317 http://zaguan.unizar.es/record/129679/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:129679 articulos driver 2025-11-13-15:00:44 ARTICLE