000129728 001__ 129728
000129728 005__ 20241125101131.0
000129728 0247_ $$2doi$$a10.1002/chem.202203667
000129728 0248_ $$2sideral$$a132791
000129728 037__ $$aART-2023-132791
000129728 041__ $$aeng
000129728 100__ $$aMalikidogo, Kyangwi P.
000129728 245__ $$aAbility of azathiacyclen ligands to stop Cu(Aß)-Induced production of reactive oxygen species: [3N1S] Is the right donor set
000129728 260__ $$c2023
000129728 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129728 5203_ $$aAlzheimer's disease (AD) is an incurable neurodegenerative disease that leads to the progressive and irreversible loss of mental functions. The amyloid beta (Aβ) peptide involved in the disease is responsible for the production of damaging reactive oxygen species (ROS) when bound to Cu ions. A therapeutic approach that consists of removing Cu ions from Aβ to alter this deleterious interaction is currently being developed. In this context, we report the ability of five different 12-membered thiaazacyclen ligands to capture Cu from Aβ and to redox silence it. We propose that the presence of a sole sulfur atom in the ligand increases the rate of Cu capture and removal from Aβ, while the kinetic aspect of the chelation was an issue encountered with the 4N parent ligand. The best ligand for removing Cu from Aβ and inhibiting the associated ROS production is the 1-thia-4,7,10-triazacyclododecane [3N1S]. Indeed the replacement of more N by S atoms makes the corresponding Cu complexes easier to reduce and thus able to produce ROS on their own. In addition, the ligand with three sulfur atoms has a weaker affinity for CuII than Aβ, and is thus unable to remove Cu from CuAβ.
000129728 536__ $$9info:eu-repo/grantAgreement/EC/H2020/638712/EU/Alzheimer's disease and Zinc: the missing link ?/aLzINK$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638712-aLzINK
000129728 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000129728 592__ $$a1.058$$b2023
000129728 593__ $$aChemistry (miscellaneous)$$c2023$$dQ1
000129728 593__ $$aOrganic Chemistry$$c2023$$dQ1
000129728 593__ $$aCatalysis$$c2023$$dQ2
000129728 590__ $$a3.9$$b2023
000129728 594__ $$a7.9$$b2023
000129728 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b80 / 231 = 0.346$$c2023$$dQ2$$eT2
000129728 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000129728 700__ $$aDrommi, Marielle
000129728 700__ $$0(orcid)0000-0002-3830-7847$$aAtrián-Blasco, Elena
000129728 700__ $$aHormann, Jan
000129728 700__ $$aKulak, Nora
000129728 700__ $$aEsmieu, Charlène
000129728 700__ $$aHureau, Christelle
000129728 773__ $$g29, 14 (2023), e202203667 [11 pp.]$$pChemistry (Weinh.)$$tChemistry - A European Journal$$x0947-6539
000129728 8564_ $$s1671571$$uhttps://zaguan.unizar.es/record/129728/files/texto_completo.pdf$$yPostprint
000129728 8564_ $$s2700676$$uhttps://zaguan.unizar.es/record/129728/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000129728 909CO $$ooai:zaguan.unizar.es:129728$$particulos$$pdriver
000129728 951__ $$a2024-11-22-11:59:05
000129728 980__ $$aARTICLE