129728 20241125101131.0 doi 10.1002/chem.202203667 sideral 132791 ART-2023-132791 eng Malikidogo, Kyangwi P. Ability of azathiacyclen ligands to stop Cu(Aß)-Induced production of reactive oxygen species: [3N1S] Is the right donor set 2023 Access copy available to the general public Unrestricted Alzheimer's disease (AD) is an incurable neurodegenerative disease that leads to the progressive and irreversible loss of mental functions. The amyloid beta (Aβ) peptide involved in the disease is responsible for the production of damaging reactive oxygen species (ROS) when bound to Cu ions. A therapeutic approach that consists of removing Cu ions from Aβ to alter this deleterious interaction is currently being developed. In this context, we report the ability of five different 12-membered thiaazacyclen ligands to capture Cu from Aβ and to redox silence it. We propose that the presence of a sole sulfur atom in the ligand increases the rate of Cu capture and removal from Aβ, while the kinetic aspect of the chelation was an issue encountered with the 4N parent ligand. The best ligand for removing Cu from Aβ and inhibiting the associated ROS production is the 1-thia-4,7,10-triazacyclododecane [3N1S]. Indeed the replacement of more N by S atoms makes the corresponding Cu complexes easier to reduce and thus able to produce ROS on their own. In addition, the ligand with three sulfur atoms has a weaker affinity for CuII than Aβ, and is thus unable to remove Cu from CuAβ. info:eu-repo/grantAgreement/EC/H2020/638712/EU/Alzheimer's disease and Zinc: the missing link ?/aLzINK This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638712-aLzINK info:eu-repo/semantics/closedAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.9 2023 CHEMISTRY, MULTIDISCIPLINARY 80 / 231 = 0.346 2023 Q2 T2 1.058 2023 Chemistry (miscellaneous) 2023 Q1 Organic Chemistry 2023 Q1 Catalysis 2023 Q2 7.9 2023 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Drommi, Marielle Atrián-Blasco, Elena (orcid)0000-0002-3830-7847 Hormann, Jan Kulak, Nora Esmieu, Charlène Hureau, Christelle 29, 14 (2023), e202203667 [11 pp.] Chemistry (Weinh.) Chemistry - A European Journal 0947-6539 1671571 http://zaguan.unizar.es/record/129728/files/texto_completo.pdf Postprint 2700676 http://zaguan.unizar.es/record/129728/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:129728 articulos driver 2024-11-22-11:59:05 ARTICLE