000129737 001__ 129737
000129737 005__ 20250923084410.0
000129737 0247_ $$2doi$$a10.3390/biom14010035
000129737 0248_ $$2sideral$$a136057
000129737 037__ $$aART-2024-136057
000129737 041__ $$aeng
000129737 100__ $$0(orcid)0000-0001-6767-8252$$aLópez-Granero, Caridad$$uUniversidad de Zaragoza
000129737 245__ $$aParticulate Matter in Human Elderly: Higher Susceptibility to Cognitive Decline and Age-Related Diseases
000129737 260__ $$c2024
000129737 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129737 5203_ $$aThis review highlights the significant impact of air quality, specifically particulate matter (PM), on cognitive decline and age-related diseases in the elderly. Despite established links to other pathologies, such as respiratory and cardiovascular illnesses, there is a pressing need for increased attention to the association between air pollution and cognitive aging, given the rising prevalence of neurocognitive disorders. PM sources are from diverse origins, including industrial activities and combustion engines, categorized into PM10, PM2.5, and ultrafine PM (UFPM), and emphasized health risks from both outdoor and indoor exposure. Long-term PM exposure, notably PM2.5, has correlated with declines in cognitive function, with a specific vulnerability observed in women. Recently, extracellular vesicles (EVs) have been explored due to the interplay between them, PM exposure, and human aging, highlighting the crucial role of EVs, especially exosomes, in mediating the complex relationship between PM exposure and chronic diseases, particularly neurological disorders. To sum up, we have compiled the pieces of evidence that show the potential contribution of PM exposure to cognitive aging and the role of EVs in mediating PM-induced cognitive impairment, which presents a promising avenue for future research and development of therapeutic strategies. Finally, this review emphasizes the need for policy changes and increased public awareness to mitigate air pollution, especially among vulnerable populations such as the elderly.
000129737 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER-PI19-00240$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113812RA-C33
000129737 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000129737 590__ $$a4.8$$b2024
000129737 592__ $$a1.333$$b2024
000129737 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b75 / 319 = 0.235$$c2024$$dQ1$$eT1
000129737 593__ $$aBiochemistry$$c2024$$dQ1
000129737 593__ $$aMolecular Biology$$c2024$$dQ2
000129737 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000129737 700__ $$aPolyanskaya, Leona
000129737 700__ $$aRuiz-Sobremazas, Diego$$uUniversidad de Zaragoza
000129737 700__ $$0(orcid)0000-0001-9320-1888$$aBarrasa, Angel$$uUniversidad de Zaragoza
000129737 700__ $$aAschner, Michael
000129737 700__ $$aAlique, Matilde
000129737 7102_ $$14009$$2740$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Social
000129737 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000129737 773__ $$g14, 1 (2024), 35 [17 pp.]$$tBiomolecules$$x2218-273X
000129737 8564_ $$s1193210$$uhttps://zaguan.unizar.es/record/129737/files/texto_completo.pdf$$yVersión publicada
000129737 8564_ $$s2628381$$uhttps://zaguan.unizar.es/record/129737/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000129737 909CO $$ooai:zaguan.unizar.es:129737$$particulos$$pdriver
000129737 951__ $$a2025-09-22-14:29:28
000129737 980__ $$aARTICLE