000129738 001__ 129738
000129738 005__ 20240109145020.0
000129738 0247_ $$2doi$$a10.1038/s41378-023-00616-x
000129738 0248_ $$2sideral$$a135984
000129738 037__ $$aART-2023-135984
000129738 041__ $$aeng
000129738 100__ $$0(orcid)0000-0002-5954-7786$$aAbizanda-Campo, Sara
000129738 245__ $$aMicrophysiological systems for solid tumor immunotherapy: opportunities and challenges
000129738 260__ $$c2023
000129738 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129738 5203_ $$aImmunotherapy remains more effective for hematologic tumors than for solid tumors. One of the main challenges to immunotherapy of solid tumors is the immunosuppressive microenvironment these tumors generate, which limits the cytotoxic capabilities of immune effector cells (e.g., cytotoxic T and natural killer cells). This microenvironment is characterized by hypoxia, nutrient starvation, accumulated waste products, and acidic pH. Tumor-hijacked cells, such as fibroblasts, macrophages, and T regulatory cells, also contribute to this inhospitable microenvironment for immune cells by secreting immunosuppressive cytokines that suppress the antitumor immune response and lead to immune evasion. Thus, there is a strong interest in developing new drugs and cell formulations that modulate the tumor microenvironment and reduce tumor cell immune evasion. Microphysiological systems (MPSs) are versatile tools that may accelerate the development and evaluation of these therapies, although specific examples showcasing the potential of MPSs remain rare. Advances in microtechnologies have led to the development of sophisticated microfluidic devices used to recapitulate tumor complexity. The resulting models, also known as microphysiological systems (MPSs), are versatile tools with which to decipher the molecular mechanisms driving immune cell antitumor cytotoxicity, immune cell exhaustion, and immune cell exclusion and to evaluate new targeted immunotherapies. Here, we review existing microphysiological platforms to study immuno-oncological applications and discuss challenges and opportunities in the field.
000129738 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2021-126051OB-C41$$9info:eu-repo/grantAgreement/EC/H2020/829010/EU/Advanced and versatile PRInting platform for the next generation of active Microfluidic dEvices/PRIME$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 829010-PRIME$$9info:eu-repo/grantAgreement/EC/H2020/876190/EU/Accelerating Innovation in Microfabricated Medical Devices/Moore4Medical$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 876190-Moore4Medical
000129738 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000129738 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000129738 700__ $$aVirumbrales-Muñoz, María
000129738 700__ $$aHumayun, Mouhita
000129738 700__ $$aMarmol, Ines
000129738 700__ $$aBeebe, David J.
000129738 700__ $$0(orcid)0000-0003-2410-5678$$aOchoa, Ignacio$$uUniversidad de Zaragoza
000129738 700__ $$0(orcid)0000-0003-0156-4230$$aOliván, Sara$$uUniversidad de Zaragoza
000129738 700__ $$aAyuso, Jose M.
000129738 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000129738 773__ $$g9, 1 (2023), 154 [30 pp.]$$pMicrosys. Nanoeng.$$tMicrosystems & Nanoengineering$$x2096-1030
000129738 8564_ $$s8362525$$uhttps://zaguan.unizar.es/record/129738/files/texto_completo.pdf$$yVersión publicada
000129738 8564_ $$s2697034$$uhttps://zaguan.unizar.es/record/129738/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000129738 909CO $$ooai:zaguan.unizar.es:129738$$particulos$$pdriver
000129738 951__ $$a2024-01-09-13:09:16
000129738 980__ $$aARTICLE