000129834 001__ 129834
000129834 005__ 20240705134209.0
000129834 0247_ $$2doi$$a10.3390/cancers15225376
000129834 0248_ $$2sideral$$a136127
000129834 037__ $$aART-2023-136127
000129834 041__ $$aeng
000129834 100__ $$aNavarro-Bielsa, Alba$$uUniversidad de Zaragoza
000129834 245__ $$aThe influence of the exposome in the cutaneous squamous cell carcinoma, a multicenter case–control study
000129834 260__ $$c2023
000129834 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129834 5203_ $$aIntroduction: The concept of exposome refers to the total of harmful and beneficial environmental exposures that can help predict the organism’s biological responses over time. Ultraviolet radiation (UVR) from sun exposure has been recognized as the main etiological agent of skin cancer, and squamous cell carcinoma (SCC) is one most commonly associated with chronic exposure. However, in recent years, evidence suggests that lifestyle, environmental pollution, and contaminants in water and food can have an influence. Objectives: To study the relationship between SCC and sun exposure, pollution, stress, and lifestyle in a Spanish cohort. Materials and Method: A multicenter case–control study was carried out in which 13 dermatologists from different regions of Spain recruited cases and controls between April 2020 and August 2022. The group of cases were patients diagnosed with SCC and, as a control group, people who attended Dermatology consultations as companions with no history of skin cancer. Results: A total of 62 patients with SCC and 126 controls were included (62.9% males, median age 76.46 (10.1) and 33.3%, median age 55.7 (15), respectively). The SCC group had experienced more outside work than the controls (75% vs. 22.4%, p < 0.001), less recreational exposure (sunbathing, p = 0.05, and outdoor sports, p = 0.01), and a lower annual income (p = 0.01), with an increase in tobacco exposure (p < 0.001), without differences in other carcinogens, such as ionizing radiation or chemical exposure. The control group had a higher daily screentime use (p < 0.001) and practiced more relaxation activities (p = 0.03). A higher linolenic acid intake and lower coffee consumption were the only dietary variables associated with SCC (p < 0.05). Some chronic medications (anxiolytics, antidepressants, beta-blockers, statins, hydrochlorothiazide, ACE inhibitors, metformin, and omeprazole) were also statistically associated with SCC. Statistical significance for all aforementioned variables was maintained in the multivariate analysis (p < 0.05). Conclusions: The study found a significant association between SCC and multiple exposome-related factors in addition to chronic sun exposure in the Spanish population. Primary prevention strategies should target specific populations, such as outdoor workers promoting sun-safe behaviors and stress-reducing activities, in addition to adequate skin photoprotection in patients under certain medications associated with SCC.
000129834 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000129834 592__ $$a1.391$$b2023
000129834 593__ $$aOncology$$c2023$$dQ1
000129834 593__ $$aCancer Research$$c2023$$dQ2
000129834 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000129834 700__ $$aGracia-Cazaña, Tamara$$uUniversidad de Zaragoza
000129834 700__ $$aAlmagro, Manuel
000129834 700__ $$aDe la Fuente-Meira, Sonia$$uUniversidad de Zaragoza
000129834 700__ $$aFlórez, Ángeles
000129834 700__ $$aYélamos, Oriol
000129834 700__ $$aMontero-Vilchez, Trinidad
000129834 700__ $$aGonzález-Cruz, Carlos
000129834 700__ $$aDiago, Adrián$$uUniversidad de Zaragoza
000129834 700__ $$aAbadías-Granado, Isabel
000129834 700__ $$aFuentelsaz, Victoria
000129834 700__ $$aColmenero, María
000129834 700__ $$aBañuls, José
000129834 700__ $$aArias-Santiago, Salvador
000129834 700__ $$aBuendía-Eisman, Agustín
000129834 700__ $$0(orcid)0000-0002-4350-401X$$aAlmenara-Blasco, Manuel$$uUniversidad de Zaragoza
000129834 700__ $$aGil-Pallares, Pedro
000129834 700__ $$0(orcid)0000-0001-8034-3617$$aGilaberte, Yolanda$$uUniversidad de Zaragoza
000129834 7102_ $$11007$$2183$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cÁrea Dermatología
000129834 773__ $$g15, 22 (2023), 5376 [16 pp.]$$pCancers$$tCancers$$x2072-6694
000129834 8564_ $$s1264943$$uhttps://zaguan.unizar.es/record/129834/files/texto_completo.pdf$$yVersión publicada
000129834 8564_ $$s2965113$$uhttps://zaguan.unizar.es/record/129834/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000129834 909CO $$ooai:zaguan.unizar.es:129834$$particulos$$pdriver
000129834 951__ $$a2024-07-05-12:51:13
000129834 980__ $$aARTICLE