000129877 001__ 129877
000129877 005__ 20240112163659.0
000129877 0247_ $$2doi$$a10.1016/j.maturitas.2017.12.007
000129877 0248_ $$2sideral$$a104141
000129877 037__ $$aART-2018-104141
000129877 041__ $$aeng
000129877 100__ $$0(orcid)0000-0002-1252-2397$$aLobo, E.$$uUniversidad de Zaragoza
000129877 245__ $$aGender differences in the association of cognitive impairment with the risk of hip fracture in the older population
000129877 260__ $$c2018
000129877 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129877 5203_ $$aObjectives: To test the hypothesis that differences by gender will be observed in the association of hip fracture risk with stages of cognitive impairment; and to explore the association between Petersen''s “mild cognitive impairment” (MCI) and DSM-5 “mild neurocognitive disorder” (MND). Study design: A community sample of 4803 individuals aged 55+ years was assessed in a two-phase case-finding enquiry in Zaragoza, Spain, and was followed up for 16 years. Medical and psychiatric history was collected with standardized instruments, including the Mini-Mental Status Examination (MMSE), Geriatric Mental State (GMS), History and Aetiology Schedule, and a Risk Factors Questionnaire. The statistical analysis included calculations of Hazard Ratios (HR) in multivariate Cox proportional hazards regression models. Main outcome measures: Identified cases of hip fracture, validated by blind researchers. Results: In men, hip fracture risk was increased at the “mild” (HR = 4.99 (1.39–17.91)) and at the “severe” (HR = 9.31 (1.35–64.06)) stages of cognitive impairment, indicated by MMSE performance. In contrast, in women no association could be documented at the “mild stage” (power = 89%), and the association disappeared altogether at the “severe stage” in the final multivariate statistical model (power 100%). No association observed between hip fracture and mild cognitive impairment in both men (power = 28% for P-MCI) and women (power = 44% and 19% for Petersen''s MCI and DSM-5 MND, respectively). Conclusions: Increased hip fracture risk was associated with “mild” stages of cognitive impairment in men, but not in women. To explore the potential association with the construct MCI or MND, studies with greater statistical power would be required.
000129877 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B35$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/FIS99-0608$$9info:eu-repo/grantAgreement/ES/ISCIII/PI10-01132
000129877 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000129877 590__ $$a3.654$$b2018
000129877 591__ $$aOBSTETRICS & GYNECOLOGY$$b9 / 82 = 0.11$$c2018$$dQ1$$eT1
000129877 591__ $$aGERIATRICS & GERONTOLOGY$$b16 / 53 = 0.302$$c2018$$dQ2$$eT1
000129877 592__ $$a1.185$$b2018
000129877 593__ $$aObstetrics and Gynecology$$c2018$$dQ1
000129877 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2018$$dQ1
000129877 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000129877 700__ $$0(orcid)0000-0001-6836-1222$$aMarcos, G.$$uUniversidad de Zaragoza
000129877 700__ $$0(orcid)0000-0002-7297-6104$$aSantabárbara, J.$$uUniversidad de Zaragoza
000129877 700__ $$aLobo-Escolar, L.
000129877 700__ $$aSalvador-Rosés, H.
000129877 700__ $$0(orcid)0000-0003-2284-7862$$aDe la Cámara, C.$$uUniversidad de Zaragoza
000129877 700__ $$0(orcid)0000-0002-3360-7015$$aLópez-Antón, R.$$uUniversidad de Zaragoza
000129877 700__ $$0(orcid)0000-0001-9822-6312$$aGracia-García, P.$$uUniversidad de Zaragoza
000129877 700__ $$0(orcid)0000-0003-3025-8048$$aLobo-Escolar, A.$$uUniversidad de Zaragoza
000129877 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000129877 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000129877 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000129877 7102_ $$11008$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Medic.Prevent.Salud Públ.
000129877 773__ $$g109 (2018), 39-44$$pMaturitas$$tMaturitas$$x0378-5122
000129877 8564_ $$s335340$$uhttps://zaguan.unizar.es/record/129877/files/texto_completo.pdf$$yPostprint
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000129877 951__ $$a2024-01-12-14:10:52
000129877 980__ $$aARTICLE