129877 20240112163659.0 doi 10.1016/j.maturitas.2017.12.007 sideral 104141 ART-2018-104141 eng Lobo, E. Universidad de Zaragoza (orcid)0000-0002-1252-2397 Gender differences in the association of cognitive impairment with the risk of hip fracture in the older population 2018 Objectives: To test the hypothesis that differences by gender will be observed in the association of hip fracture risk with stages of cognitive impairment; and to explore the association between Petersen''s “mild cognitive impairment” (MCI) and DSM-5 “mild neurocognitive disorder” (MND). Study design: A community sample of 4803 individuals aged 55+ years was assessed in a two-phase case-finding enquiry in Zaragoza, Spain, and was followed up for 16 years. Medical and psychiatric history was collected with standardized instruments, including the Mini-Mental Status Examination (MMSE), Geriatric Mental State (GMS), History and Aetiology Schedule, and a Risk Factors Questionnaire. The statistical analysis included calculations of Hazard Ratios (HR) in multivariate Cox proportional hazards regression models. Main outcome measures: Identified cases of hip fracture, validated by blind researchers. Results: In men, hip fracture risk was increased at the “mild” (HR = 4.99 (1.39–17.91)) and at the “severe” (HR = 9.31 (1.35–64.06)) stages of cognitive impairment, indicated by MMSE performance. In contrast, in women no association could be documented at the “mild stage” (power = 89%), and the association disappeared altogether at the “severe stage” in the final multivariate statistical model (power 100%). No association observed between hip fracture and mild cognitive impairment in both men (power = 28% for P-MCI) and women (power = 44% and 19% for Petersen''s MCI and DSM-5 MND, respectively). Conclusions: Increased hip fracture risk was associated with “mild” stages of cognitive impairment in men, but not in women. To explore the potential association with the construct MCI or MND, studies with greater statistical power would be required. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA/B35 info:eu-repo/grantAgreement/ES/ISCIII/FIS/01-0255 info:eu-repo/grantAgreement/ES/ISCIII/FIS/94-1562 info:eu-repo/grantAgreement/ES/ISCIII/FIS/97-1321E info:eu-repo/grantAgreement/ES/ISCIII/FIS/FIS99-0608 info:eu-repo/grantAgreement/ES/ISCIII/PI10-01132 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.654 2018 OBSTETRICS & GYNECOLOGY 9 / 82 = 0.11 2018 Q1 T1 GERIATRICS & GERONTOLOGY 16 / 53 = 0.302 2018 Q2 T1 1.185 2018 Obstetrics and Gynecology 2018 Q1 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Marcos, G. Universidad de Zaragoza (orcid)0000-0001-6836-1222 Santabárbara, J. Universidad de Zaragoza (orcid)0000-0002-7297-6104 Lobo-Escolar, L. Salvador-Rosés, H. De la Cámara, C. Universidad de Zaragoza (orcid)0000-0003-2284-7862 López-Antón, R. Universidad de Zaragoza (orcid)0000-0002-3360-7015 Gracia-García, P. Universidad de Zaragoza (orcid)0000-0001-9822-6312 Lobo-Escolar, A. Universidad de Zaragoza (orcid)0000-0003-3025-8048 4009 730 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Básica 1003 027 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Anatom.Embriol.Humana 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 1008 615 Universidad de Zaragoza Dpto. Microb.Med.Pr.,Sal.Públ. Área Medic.Prevent.Salud Públ. 109 (2018), 39-44 Maturitas Maturitas 0378-5122 335340 http://zaguan.unizar.es/record/129877/files/texto_completo.pdf Postprint 1163721 http://zaguan.unizar.es/record/129877/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:129877 articulos driver 2024-01-12-14:10:52 ARTICLE