000129915 001__ 129915
000129915 005__ 20241125101148.0
000129915 0247_ $$2doi$$a10.1186/s13567-023-01225-2
000129915 0248_ $$2sideral$$a136249
000129915 037__ $$aART-2023-136249
000129915 041__ $$aeng
000129915 100__ $$0(orcid)0000-0002-0388-9429$$aBetancor, Marina$$uUniversidad de Zaragoza
000129915 245__ $$aDetection of classical BSE prions in asymptomatic cows after inoculation with atypical/Nor98 scrapie
000129915 260__ $$c2023
000129915 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129915 5203_ $$aThe emergence of bovine spongiform encephalopathy (BSE) prions from atypical scrapie has been recently observed upon experimental transmission to rodent and swine models. This study aimed to assess whether the inoculation of atypical scrapie could induce BSE-like disease in cattle. Four calves were intracerebrally challenged with atypical scrapie. Animals were euthanized without clinical signs of prion disease and tested negative for PrPSc accumulation by immunohistochemistry and western blotting. However, an emergence of BSE-like prion seeding activity was detected during in vitro propagation of brain samples from the inoculated animals. These findings suggest that atypical scrapie may represent a potential source of BSE infection in cattle.
000129915 536__ $$9info:eu-repo/grantAgreement/EUR/INTERREG-POCTEFA/EFA-148-16 REDPRION$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-125398OB-I00
000129915 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000129915 590__ $$a3.7$$b2023
000129915 592__ $$a0.907$$b2023
000129915 591__ $$aVETERINARY SCIENCES$$b10 / 167 = 0.06$$c2023$$dQ1$$eT1
000129915 593__ $$aVeterinary (miscellaneous)$$c2023$$dQ1
000129915 594__ $$a7.0$$b2023
000129915 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000129915 700__ $$0(orcid)0000-0002-1590-3347$$aMarín, Belén$$uUniversidad de Zaragoza
000129915 700__ $$0(orcid)0000-0001-9075-2764$$aOtero, Alicia$$uUniversidad de Zaragoza
000129915 700__ $$0(orcid)0000-0002-0827-110X$$aHedman, Carlos$$uUniversidad de Zaragoza
000129915 700__ $$0(orcid)0000-0001-7188-0461$$aRomero, Antonio$$uUniversidad de Zaragoza
000129915 700__ $$aBarrio, Tomás
000129915 700__ $$0(orcid)0000-0002-4213-2904$$aSevilla, Eloisa$$uUniversidad de Zaragoza
000129915 700__ $$aDouet, Jean-Yves
000129915 700__ $$aHuor, Alvina
000129915 700__ $$0(orcid)0000-0002-7173-7216$$aBadiola, Juan José$$uUniversidad de Zaragoza
000129915 700__ $$aAndréoletti, Olivier
000129915 700__ $$0(orcid)0000-0002-2746-3932$$aBolea, Rosa$$uUniversidad de Zaragoza
000129915 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000129915 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal
000129915 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000129915 773__ $$g54, 89 (2023), 1-7$$pVet. res.$$tVeterinary Research$$x0928-4249
000129915 8564_ $$s972767$$uhttps://zaguan.unizar.es/record/129915/files/texto_completo.pdf$$yVersión publicada
000129915 8564_ $$s2570530$$uhttps://zaguan.unizar.es/record/129915/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000129915 909CO $$ooai:zaguan.unizar.es:129915$$particulos$$pdriver
000129915 951__ $$a2024-11-22-12:05:33
000129915 980__ $$aARTICLE