000129936 001__ 129936
000129936 005__ 20240116090136.0
000129936 0247_ $$2doi$$a10.1016/j.pain.2014.09.004
000129936 0248_ $$2sideral$$a95855
000129936 037__ $$aART-2014-95855
000129936 041__ $$aeng
000129936 100__ $$0(orcid)0000-0001-6565-9699$$aOliván-Blázquez, B$$uUniversidad de Zaragoza
000129936 245__ $$aEfficacy of memantine in the treatment of fibromyalgia: A double-blind, randomised, controlled trial with 6-month follow-up.
000129936 260__ $$c2014
000129936 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129936 5203_ $$aFibromyalgia (FM) is a prevalent and disabling chronic disease. Recent studies have found elevated levels of glutamate in several brain regions, leading to hypotheses about the usefulness of glutamate-blocking drugs such as memantine in the treatment of FM. The aim of this study was to evaluate the efficacy of memantine in the treatment of pain and other clinical variables (global function, clinical impression, depression, anxiety, quality of life) in FM patients. A double-blind, parallel randomised controlled trial was developed. A total of 63 patients diagnosed with FM were recruited from primary health care centres in Zaragoza, Spain. Memantine was administered at doses of 20mg/d after 1 month of titration. Assessments were carried out at baseline, posttreatment, and 3- and 6-month follow-up. Compared with a placebo group, memantine significantly decreased ratings on a pain visual analogue scale (Cohen's d=1.43 at 6 months) and pain measured with a sphygmomanometer (d=1.05). All other secondary outcomes except anxiety also improved, with moderate-to-large effect sizes at 6 months. Compared with placebo, the absolute risk reduction obtained with memantine was 16.13% (95% confidence interval=2.0% to 32.6%), and the number needed to treat was 6.2 (95% confidence interval=3 to 47). Tolerance was good, with dizziness (8 patients) and headache (4 patients) being the most frequent side effects of memantine. Although additional studies with larger sample sizes and longer follow-up times are needed, this study provides preliminary evidence of the utility of memantine for the treatment of FM.
000129936 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000129936 590__ $$a5.213$$b2014
000129936 591__ $$aANESTHESIOLOGY$$b2 / 30 = 0.067$$c2014$$dQ1$$eT1
000129936 591__ $$aNEUROSCIENCES$$b35 / 251 = 0.139$$c2014$$dQ1$$eT1
000129936 591__ $$aCLINICAL NEUROLOGY$$b17 / 191 = 0.089$$c2014$$dQ1$$eT1
000129936 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000129936 700__ $$0(orcid)0000-0003-2088-4272$$aHerrera-Mercadal, P$$uUniversidad de Zaragoza
000129936 700__ $$0(orcid)0000-0002-8862-7240$$aPuebla-Guedea, M
000129936 700__ $$0(orcid)0000-0001-5566-9746$$aPérez-Yus, MC$$uUniversidad de Zaragoza
000129936 700__ $$aAndrés, E
000129936 700__ $$aFayed, N
000129936 700__ $$0(orcid)0000-0002-1690-4130$$aLópez-Del-Hoyo, Y$$uUniversidad de Zaragoza
000129936 700__ $$0(orcid)0000-0002-5494-6550$$aMagallon, R$$uUniversidad de Zaragoza
000129936 700__ $$aRoca, M
000129936 700__ $$0(orcid)0000-0002-3797-4218$$aGarcia-Campayo, J.$$uUniversidad de Zaragoza
000129936 7102_ $$14009$$2740$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Social
000129936 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000129936 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000129936 7102_ $$10$$2X$$aUniversidad de Zaragoza$$bEstudios propios$$cEstudios Propios Dpto.M.Ps.y D
000129936 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000129936 7102_ $$14009$$2680$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Person.Eval.Trat.Psicoló.
000129936 773__ $$g155, 12 (2014), 2517-25$$pPain$$tPAIN$$x0304-3959
000129936 8564_ $$s1204000$$uhttps://zaguan.unizar.es/record/129936/files/texto_completo.pdf$$yPostprint
000129936 8564_ $$s1009236$$uhttps://zaguan.unizar.es/record/129936/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000129936 909CO $$ooai:zaguan.unizar.es:129936$$particulos$$pdriver
000129936 951__ $$a2024-01-16-08:23:59
000129936 980__ $$aARTICLE