000129938 001__ 129938
000129938 005__ 20240116090136.0
000129938 0247_ $$2doi$$a10.1016/j.clnu.2016.01.018
000129938 0248_ $$2sideral$$a98545
000129938 037__ $$aART-2017-98545
000129938 041__ $$aeng
000129938 100__ $$0(orcid)0000-0001-6650-8294$$aMateo-Gallego, R.$$uUniversidad de Zaragoza
000129938 245__ $$aEnergy-restricted, high-protein diets more effectively impact cardiometabolic profile in overweight and obese women than lower-protein diets
000129938 260__ $$c2017
000129938 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129938 5203_ $$aBackground & aims High-protein energy-restricted diets have demonstrated efficacy in promoting weight loss in overweight and obesity. However, the protein percentage that achieves optimal efficacy and acceptability remains unknown. We sought to assess the effects of three energy-reduced diets with different percentages of calories from protein (20%, 27%, and 35%) on weight loss and lipids. Secondary outcomes included diet acceptability and compliance. Methods Six-month, randomized study included women aged 18–80 years with BMI of 27.5–45 kg/m2 and who were not taking lipid-lowering drugs. We randomly assigned 91 women to one of three calorie-reduced diets with: protein, 20%, 27%, or 35% (80% from animal protein); carbohydrates, 50%, 43%, or 35%; fat, 30%. Dietary intervention involved individual visits with a nutritionist every 2 weeks during the first 3 months. We performed a follow-up visit at 6 months. Results Eighty women aged 44.0 ± 9.08 years with BMI of 37.7 ± 3.39 kg/m2 completed the study. At 3 months, weight loss was -8.16 ± 4.18 kg, -9.66 ± 5.28 kg, and -10.7 ± 4.28 kg in the 20%, 27%, and 35%-protein groups, respectively (P = 0.16). These figures slightly and homogeneously increased at 6 months. Around 65% of women following 35%-protein diet lost =10% of body weight vs. ~33% in 20%-protein group (P = 0.023). Significant decreases occurred in fat mass, lipids and insulin resistance, especially in the 35%-protein group (P < 0.05 vs. 20% protein). This improvement was not fully explained by weight loss. Triglyceride change was negatively correlated with animal-protein intake. All groups provided similar responses to an acceptance, palatability, and satisfaction questionnaire. Conclusions An energy-restricted diet with 35% protein, mostly of animal origin, more effectively impacts cardiometabolic profile than an energy-restricted diet with lower protein content although no clear benefit between diets in terms of overall weight loss was observed. The high-protein diet displayed an excellent safety profile and acceptability. This trial was registered in ClinicalTrials.gov as NCT02160496. Clinical trial registration The clinical trial has been registered in ClinicalTrials.gov (Identifier: NCT02160496).
000129938 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI12-01087$$9info:eu-repo/grantAgreement/ES/FIS/RETIC-RD12-0042-0055
000129938 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000129938 590__ $$a5.496$$b2017
000129938 591__ $$aNUTRITION & DIETETICS$$b8 / 79 = 0.101$$c2017$$dQ1$$eT1
000129938 592__ $$a1.905$$b2017
000129938 593__ $$aNutrition and Dietetics$$c2017$$dQ1
000129938 593__ $$aCritical Care and Intensive Care Medicine$$c2017$$dQ1
000129938 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000129938 700__ $$aMarco-Benedí, V.
000129938 700__ $$0(orcid)0000-0002-1894-1621$$aPérez-Calahorra, S.
000129938 700__ $$aBea, A. M.
000129938 700__ $$aBaila-Rueda, L.
000129938 700__ $$0(orcid)0000-0002-9647-0108$$aLamiquiz-Moneo, I.
000129938 700__ $$0(orcid)0000-0001-6845-9334$$ade Castro-Orós, I.
000129938 700__ $$aCenarro, A.
000129938 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, F.$$uUniversidad de Zaragoza
000129938 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000129938 773__ $$g36, 2 (2017), 371-379$$pClin. nutr.$$tClinical Nutrition$$x0261-5614
000129938 8564_ $$s650513$$uhttps://zaguan.unizar.es/record/129938/files/texto_completo.pdf$$yPostprint
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000129938 909CO $$ooai:zaguan.unizar.es:129938$$particulos$$pdriver
000129938 951__ $$a2024-01-16-08:24:06
000129938 980__ $$aARTICLE