000129954 001__ 129954
000129954 005__ 20240116090136.0
000129954 0247_ $$2doi$$a10.1016/j.clnu.2014.05.011
000129954 0248_ $$2sideral$$a90434
000129954 037__ $$aART-2015-90434
000129954 041__ $$aeng
000129954 100__ $$aMateo-Gallego, R.
000129954 245__ $$aSerum plant sterols as surrogate markers of dietary compliance infamilial dyslipidemias
000129954 260__ $$c2015
000129954 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129954 5203_ $$aBackground & aims: A well-balanced diet is the first-line treatment in hyperlipidemia. The objective was to study the association between serum phytosterols and dietary patterns to use them as surrogate markers of dietary compliance in primary dyslipidemias. Methods: 288 patients with primary hyperlipidemias (192 autosomal dominant hypercholesterolemia (ADH) and 96 familial combined hyperlipidemia (FCHL)) were included. Principal factor analysis identified 2 major dietary patterns using a 137-item food frequency questionnaire. “Vegetable & Fruits pattern” was characterized by higher intake of fruits, green beans, nuts, tomatoes, roasted or boiled potatoes, lettuce and chard and lower of processed baked goods, pizza and beer. “Western pattern” was positively characterized by hamburgers, pasta, sunflower oil, rice, chickpeas, whole milk, veal, red beans and negatively with white fish. Serum non-cholesterol sterols were determined by HPLC-MS/MS. Results: Plant sterols to-total cholesterol (TC) levels were lower with a higher adherence to a “Vegetable & Fruits pattern” (P = 0.009), mainly in ADH subjects (R2 = 0.019). Their concentration was greater with higher compliance to “Western pattern” especially in FCHL (P = 0.014). Higher levels of synthesis markers-to-TC with a greater adherence to “Vegetable & Fruits pattern” were found (P = 0.001) (R2 = 0.033 and R2 = 0.109 in ADH and FCHL respectively). Conclusion: In subjects with primary dislipidemia, dietary patterns associate with serum absorption and synthesis markers, but no with lipid concentrations. The influence of diet on non-cholesterol sterols levels is not powerful enough to use them as subrogate markers.
000129954 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI12-01087$$9info:eu-repo/grantAgreement/ES/FIS/RETIC-RD12-0042-0055
000129954 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000129954 590__ $$a4.487$$b2015
000129954 591__ $$aNUTRITION & DIETETICS$$b10 / 80 = 0.125$$c2015$$dQ1$$eT1
000129954 592__ $$a1.79$$b2015
000129954 593__ $$aNutrition and Dietetics$$c2015$$dQ1
000129954 593__ $$aCritical Care and Intensive Care Medicine$$c2015$$dQ1
000129954 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000129954 700__ $$0(orcid)0000-0001-6650-8294$$aBaila-Rueda, L.
000129954 700__ $$aMouratidou, T.
000129954 700__ $$0(orcid)0000-0002-3726-1066$$aDe Castro-Orós, I.
000129954 700__ $$aBea, A. M.
000129954 700__ $$0(orcid)0000-0001-6845-9334$$aPérez-Calahorra, S.$$uUniversidad de Zaragoza
000129954 700__ $$0(orcid)0000-0002-1894-1621$$aCenarro, A.
000129954 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L. A.$$uUniversidad de Zaragoza
000129954 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, F.$$uUniversidad de Zaragoza
000129954 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000129954 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000129954 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000129954 773__ $$g34, 3 (2015), 490-495$$pClin. nutr.$$tClinical Nutrition$$x0261-5614
000129954 8564_ $$s603919$$uhttps://zaguan.unizar.es/record/129954/files/texto_completo.pdf$$yPostprint
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000129954 951__ $$a2024-01-16-08:25:12
000129954 980__ $$aARTICLE