000129970 001__ 129970
000129970 005__ 20240705134210.0
000129970 0247_ $$2doi$$a10.1016/j.nut.2023.112211
000129970 0248_ $$2sideral$$a136252
000129970 037__ $$aART-2023-136252
000129970 041__ $$aeng
000129970 100__ $$0(orcid)0000-0002-8100-5596$$aMartínez-Beamonte, Roberto$$uUniversidad de Zaragoza
000129970 245__ $$aDietary proteins modulate high-density lipoprotein characteristics in a sex-specific way in Apoe-deficient mice
000129970 260__ $$c2023
000129970 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129970 5203_ $$aObjectives: The type and amount of dietary protein have become a topic of renewed interest, considering their involvement in several diseases. However, little attention has been devoted to the effect of avian proteins despite their wide human consumption. In a previous study, we saw that compared with soybean protein, the consumption of avian proteins, depending on sex, resulted in similar or lower atherosclerosis with a higher paraoxonase 1 activity, an antioxidant enzyme carried by high-density lipoproteins (HDL). This suggests that under these conditions, the HDL lipoproteins may undergo important changes. The aim of this research was to study the influence of soybean, chicken, and turkey proteins on the characteristics of HDL.
Methods: Male and female Apoe-deficient mice were fed purified Western diets based on the AIN-93 diet, differing only in the protein source, for 12 wk. After this period, blood and liver samples were taken for analysis of HDL composition and hepatic expression of genes related to HDL metabolism (Abca1, Lcat, Pltp, Pon1, and Scarb1). Depending on sex, these genes define a different network of interactions. Females consuming the turkey protein–containing diet showed decreased atherosclerotic foci, which can be due to larger very-low-density lipoproteins (VLDLs) calculated by molar ratio triacylglycerols/VLDL cholesterol and higher expression of Lcat. In contrast, in males, a higher ratio of paraoxonase1 to apolipoprotein A1 decreased the oxidative status of the different lipoproteins, and augmented Abca1 expression was observed.
Conclusions: The source of protein has an effect on the development of atherosclerosis depending on sex by modifying HDL characteristics and the expression of genes involved in their properties.
000129970 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000129970 592__ $$a0.925$$b2023
000129970 593__ $$aNutrition and Dietetics$$c2023$$dQ2
000129970 593__ $$aEndocrinology, Diabetes and Metabolism$$c2023$$dQ2
000129970 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000129970 700__ $$0(orcid)0000-0002-9023-741X$$aSánchez-Marco, Javier
000129970 700__ $$aGómez, Marta
000129970 700__ $$aLázaro, Gonzalo
000129970 700__ $$aBarco, María
000129970 700__ $$aHerrero-Continente, Tania
000129970 700__ $$aSerrano-Megías, Marta
000129970 700__ $$aBotaya, David
000129970 700__ $$0(orcid)0000-0003-1197-4276$$aArnal, Carmen$$uUniversidad de Zaragoza
000129970 700__ $$aBarranquero, Cristina
000129970 700__ $$0(orcid)0000-0002-5841-0462$$aSurra, Joaquín C.$$uUniversidad de Zaragoza
000129970 700__ $$aManso-Alonso, José Antonio
000129970 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, Jesús$$uUniversidad de Zaragoza
000129970 700__ $$0(orcid)0000-0002-0108-1004$$aNavarro, María A.$$uUniversidad de Zaragoza
000129970 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000129970 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal
000129970 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000129970 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular
000129970 773__ $$g116 (2023), 112211 [7 pp.]$$pNutrition$$tNUTRITION$$x0899-9007
000129970 8564_ $$s1119763$$uhttps://zaguan.unizar.es/record/129970/files/texto_completo.pdf$$yVersión publicada
000129970 8564_ $$s2539832$$uhttps://zaguan.unizar.es/record/129970/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000129970 909CO $$ooai:zaguan.unizar.es:129970$$particulos$$pdriver
000129970 951__ $$a2024-07-05-12:51:21
000129970 980__ $$aARTICLE