129970 20241125101148.0 doi 10.1016/j.nut.2023.112211 sideral 136252 ART-2023-136252 eng Martínez-Beamonte, Roberto Universidad de Zaragoza (orcid)0000-0002-8100-5596 Dietary proteins modulate high-density lipoprotein characteristics in a sex-specific way in Apoe-deficient mice 2023 Access copy available to the general public Unrestricted Objectives: The type and amount of dietary protein have become a topic of renewed interest, considering their involvement in several diseases. However, little attention has been devoted to the effect of avian proteins despite their wide human consumption. In a previous study, we saw that compared with soybean protein, the consumption of avian proteins, depending on sex, resulted in similar or lower atherosclerosis with a higher paraoxonase 1 activity, an antioxidant enzyme carried by high-density lipoproteins (HDL). This suggests that under these conditions, the HDL lipoproteins may undergo important changes. The aim of this research was to study the influence of soybean, chicken, and turkey proteins on the characteristics of HDL. Methods: Male and female Apoe-deficient mice were fed purified Western diets based on the AIN-93 diet, differing only in the protein source, for 12 wk. After this period, blood and liver samples were taken for analysis of HDL composition and hepatic expression of genes related to HDL metabolism (Abca1, Lcat, Pltp, Pon1, and Scarb1). Depending on sex, these genes define a different network of interactions. Females consuming the turkey protein–containing diet showed decreased atherosclerotic foci, which can be due to larger very-low-density lipoproteins (VLDLs) calculated by molar ratio triacylglycerols/VLDL cholesterol and higher expression of Lcat. In contrast, in males, a higher ratio of paraoxonase1 to apolipoprotein A1 decreased the oxidative status of the different lipoproteins, and augmented Abca1 expression was observed. Conclusions: The source of protein has an effect on the development of atherosclerosis depending on sex by modifying HDL characteristics and the expression of genes involved in their properties. info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.2 2023 NUTRITION & DIETETICS 50 / 114 = 0.439 2023 Q2 T2 0.925 2023 Nutrition and Dietetics 2023 Q2 Endocrinology, Diabetes and Metabolism 2023 Q2 7.8 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Sánchez-Marco, Javier (orcid)0000-0002-9023-741X Gómez, Marta Lázaro, Gonzalo Barco, María Herrero-Continente, Tania Serrano-Megías, Marta Botaya, David Arnal, Carmen Universidad de Zaragoza (orcid)0000-0003-1197-4276 Barranquero, Cristina Surra, Joaquín C. Universidad de Zaragoza (orcid)0000-0002-5841-0462 Manso-Alonso, José Antonio Osada, Jesús Universidad de Zaragoza (orcid)0000-0002-8251-8457 Navarro, María A. Universidad de Zaragoza (orcid)0000-0002-0108-1004 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 2008 700 Universidad de Zaragoza Dpto. Produc.Animal Cienc.Ali. Área Producción Animal 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 1002 050 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Biología Celular 116 (2023), 112211 [7 pp.] Nutrition NUTRITION 0899-9007 1119763 http://zaguan.unizar.es/record/129970/files/texto_completo.pdf Versión publicada 2539832 http://zaguan.unizar.es/record/129970/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:129970 articulos driver 2024-11-22-12:05:34 ARTICLE