000129986 001__ 129986 000129986 005__ 20240118092026.0 000129986 0247_ $$2doi$$a10.1016/j.jnutbio.2014.04.005 000129986 0248_ $$2sideral$$a86879 000129986 037__ $$aART-2014-86879 000129986 041__ $$aeng 000129986 100__ $$0(orcid)0000-0003-0156-4230$$aOliván, S.$$uUniversidad de Zaragoza 000129986 245__ $$aExtra virgin olive oil intake delays the development of amyotrophic lateral sclerosis associated with reduced reticulum stress and autophagy in muscle of SOD1G93A mice 000129986 260__ $$c2014 000129986 5060_ $$aAccess copy available to the general public$$fUnrestricted 000129986 5203_ $$aAmyotrophic lateral sclerosis is a neurodegenerative disease associated with mutations in antioxidant enzyme Cu/Zn-superoxide dismutase 1.Albeit there is no treatment for this disease, new insights related to an exacerbated lipid metabolism have been reported. In connection with the hypermetabolic lipid status,the hypothesis whether nature of dietary fat might delay the progression of the disease was tested by using a transgenic mouse that overexpresses the human SOD1G93A variant. For this purpose, SOD1G93A mice were assigned randomly to one of the following three experimental groups: (1) a standard chow diet (control, n=21), (2) a chow diet enriched with 20% (w/w) extra virgin olive oil (EVOO, n=22) and (3) a chow diet containing 20% palm oil (palm, n=20). They received the diets for 8 weeks and the progression of the disease was assessed. On the standard chow diet, average plasma cholesterol levels were lower than those mice receiving the high-fat diets. Mice fed an EVOO diet showed a significant higher survival and better motor performance than control mice. EVOO group mice survived longer and showed better motor performance and larger muscle fiber area than animals receiving palm. Moreover, the EVOO-enriched diet improved the muscle status as shown by expression of myogenic factors (Myod1 and Myog) and autophagy markers (LC3 and Beclin1), as well as diminished endoplasmic reticulum (ER) stress through decreasing Atf6 and Grp78. Our results demonstrate that EVOO may be effective in increasing survival rate, improving motor coordination together with a potential amelioration of ER stress, autophagy and muscle damage. 000129986 536__ $$9info:eu-repo/grantAgreement/ES/CICYT-FEDER/SAF 2010-14958$$9info:eu-repo/grantAgreement/ES/DGA-FSE/B69$$9info:eu-repo/grantAgreement/ES/DGA/PI025-08$$9info:eu-repo/grantAgreement/ES/ISCIII/PI10-01787$$9info:eu-repo/grantAgreement/ES/MINECO/INNPACTO-IPT-2011-1091-900000 000129986 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000129986 590__ $$a3.794$$b2014 000129986 591__ $$aNUTRITION & DIETETICS$$b14 / 77 = 0.182$$c2014$$dQ1$$eT1 000129986 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b85 / 290 = 0.293$$c2014$$dQ2$$eT1 000129986 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000129986 700__ $$0(orcid)0000-0002-8100-5596$$aMartínez-Beamonte, R.$$uUniversidad de Zaragoza 000129986 700__ $$0(orcid)0000-0001-5193-7782$$aCalvo, A. C.$$uUniversidad de Zaragoza 000129986 700__ $$0(orcid)0000-0002-5841-0462$$aSurra, J. C.$$uUniversidad de Zaragoza 000129986 700__ $$0(orcid)0000-0002-7477-8742$$aManzano, R. 000129986 700__ $$0(orcid)0000-0003-1197-4276$$aArnal, C.$$uUniversidad de Zaragoza 000129986 700__ $$0(orcid)0000-0001-5687-6704$$aOsta, R.$$uUniversidad de Zaragoza 000129986 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, J.$$uUniversidad de Zaragoza 000129986 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética 000129986 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal 000129986 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal 000129986 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole. 000129986 773__ $$g25, 8 (2014), 885-892$$pJ. nutr. biochem.$$tJournal of Nutritional Biochemistry$$x0955-2863 000129986 8564_ $$s449219$$uhttps://zaguan.unizar.es/record/129986/files/texto_completo.pdf$$yPostprint 000129986 8564_ $$s1081517$$uhttps://zaguan.unizar.es/record/129986/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000129986 909CO $$ooai:zaguan.unizar.es:129986$$particulos$$pdriver 000129986 951__ $$a2024-01-18-09:04:02 000129986 980__ $$aARTICLE