000129987 001__ 129987
000129987 005__ 20240124152520.0
000129987 0247_ $$2doi$$a10.1016/j.jnutbio.2013.07.010
000129987 0248_ $$2sideral$$a83832
000129987 037__ $$aART-2013-83832
000129987 041__ $$aeng
000129987 100__ $$0(orcid)0000-0002-2348-8702$$aGabás Rivera, Clara$$uUniversidad de Zaragoza
000129987 245__ $$aDietary oleanolic acid mediates circadian clock gene expression in liver independently of diet and animal model but requires apolipoprotein A1
000129987 260__ $$c2013
000129987 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129987 5203_ $$aOleanolic acid is a triterpene widely distributed throughout the plant kingdom and present in virgin olive oil at a concentration of 57 mg/kg. To test the hypotheses that its long-term administration could modify hepatic gene expression in several animal models and that this could be influenced by the presence of APOA1-containing high-density lipoproteins (HDLs), diets including 0.01% oleanolic acid were provided to Apoe- and Apoa1-deficient mice and F344 rats. Hepatic transcriptome was analyzed in Apoe-deficient mice fed long-term semipurified Western diets differing in the oleanolic acid content. Gene expression changes, confirmed by reverse transcriptase quantitative polymerase chain reaction, were sought for their implication in hepatic steatosis. To establish the effect of oleanolic acid independently of diet and animal model, male rats were fed chow diet with or without oleanolic acid, and to test the influence of HDL, Apoa1-deficient mice consuming the latter diet were used. In Apoe-deficient mice, oleanolic acid intake increased hepatic area occupied by lipid droplets with no change in oxidative stress. Bmal1 and the other core component of the circadian clock, Clock, together with Elovl3, Tubb2a and Cldn1 expressions, were significantly
increased, while Amy2a5, Usp2, Per3 and Thrsp were significantly decreased in mice receiving the compound. Bmal1 and Cldn1 expressions were positively associated with lipid droplets. Increased Clock and Bmal1 expressions were also observed in rats, but not in Apoa1-deficient mice. The core liver clock components Clock-Bmal1 are a target of oleanolic acid in two animal models independently of the diets provided, and this compound requires APOA1-HDL for its hepatic action.
000129987 536__ $$9info:eu-repo/grantAgreement/ES/CICYT-FEDER/SAF 2010-14958$$9info:eu-repo/grantAgreement/ES/DGA/B69$$9info:eu-repo/grantAgreement/ES/DGA/PI025-08
000129987 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000129987 590__ $$a4.592$$b2013
000129987 591__ $$aNUTRITION & DIETETICS$$b9 / 78 = 0.115$$c2013$$dQ1$$eT1
000129987 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b66 / 290 = 0.228$$c2013$$dQ1$$eT1
000129987 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000129987 700__ $$0(orcid)0000-0002-8100-5596$$aMartínez Beamonte, Roberto$$uUniversidad de Zaragoza
000129987 700__ $$aRíos, José L
000129987 700__ $$0(orcid)0000-0002-0108-1004$$aNavarro, María A$$uUniversidad de Zaragoza
000129987 700__ $$0(orcid)0000-0002-5841-0462$$aSurra, Joaquín C$$uUniversidad de Zaragoza
000129987 700__ $$0(orcid)0000-0002-5152-1071$$aArnal, Carmen$$uUniversidad de Zaragoza
000129987 700__ $$0(orcid)0000-0002-3595-7668$$aRodríguez Yoldi, María J$$uUniversidad de Zaragoza
000129987 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, Jesús$$uUniversidad de Zaragoza
000129987 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Microbiología
000129987 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000129987 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal
000129987 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000129987 773__ $$g24, 12 (2013), 2100-2109$$pJ. nutr. biochem.$$tJournal of Nutritional Biochemistry$$x0955-2863
000129987 8564_ $$s1062245$$uhttps://zaguan.unizar.es/record/129987/files/texto_completo.pdf$$yPostprint
000129987 8564_ $$s1712941$$uhttps://zaguan.unizar.es/record/129987/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000129987 909CO $$ooai:zaguan.unizar.es:129987$$particulos$$pdriver
000129987 951__ $$a2024-01-24-15:16:21
000129987 980__ $$aARTICLE