000129998 001__ 129998
000129998 005__ 20240118092026.0
000129998 0247_ $$2doi$$a10.1002/mnfr.202000354
000129998 0248_ $$2sideral$$a120569
000129998 037__ $$aART-2020-120569
000129998 041__ $$aeng
000129998 100__ $$0(orcid)0000-0002-2348-8702$$aGabás-Rivera, C.
000129998 245__ $$aDietary Squalene Induces Cytochromes Cyp2b10 and Cyp2c55 Independently of Sex, Dose, and Diet in Several Mouse Models
000129998 260__ $$c2020
000129998 5060_ $$aAccess copy available to the general public$$fUnrestricted
000129998 5203_ $$aScope: To investigate the effects of squalene, the main hydrocarbon present in extra virgin olive oil, on liver transcriptome in different animal models and to test the influence of sex on this action and its relationship with hepatic lipids. Methods and Results: To this purpose, male C57BL/6J Apoe-deficient mice are fed a purified Western diet with or without squalene during 11 weeks and hepatic squalene content is assessed, so are hepatic lipids and lipid droplets. Hepatic transcriptomic changes are studied and confirmed by RT-qPCR. Dietary characteristics and influence of squalene doses are tested in Apoe-deficient on purified chow diets with or without squalene. These diets are also given to Apoa1 and wild-type mice on C57BL/6J background and to C57BL/6J xOla129 Apoe-deficient mice. Squalene supplementation increases its hepatic content without differences among sexes and hormonal status. The Cyp2b10 and Cyp2c55 gene expressions are significantly up-regulated by the squalene intake in all models, with independence of sex, sexual hormones, dietary fat content, genetic background and dose, and in Apoe-deficient mice consuming extra-virgin olive oil. Conclusion: Hepatic squalene increases the expression of these cytochromes and their changes in virgin olive oil diets may be due to their squalene content.
000129998 536__ $$9info:eu-repo/grantAgreement/ES/CIBERObn/CB06-03-1012$$9info:eu-repo/grantAgreement/ES/DGA-FSE/B16-20R$$9info:eu-repo/grantAgreement/ES/ISCIII/CB16-10-00269$$9info:eu-repo/grantAgreement/ES/MINECO/PID2019-104915RB-I00$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75441-R
000129998 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000129998 590__ $$a5.914$$b2020
000129998 591__ $$aFOOD SCIENCE & TECHNOLOGY$$b16 / 143 = 0.112$$c2020$$dQ1$$eT1
000129998 592__ $$a1.495$$b2020
000129998 593__ $$aFood Science$$c2020$$dQ1
000129998 593__ $$aBiotechnology$$c2020$$dQ1
000129998 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000129998 700__ $$aJurado-Ruiz, E.
000129998 700__ $$aSánchez-Ortiz, A.
000129998 700__ $$aRomanos, E.$$uUniversidad de Zaragoza
000129998 700__ $$0(orcid)0000-0002-8100-5596$$aMartínez-Beamonte, R.$$uUniversidad de Zaragoza
000129998 700__ $$0(orcid)0000-0002-0108-1004$$aNavarro, M.A.$$uUniversidad de Zaragoza
000129998 700__ $$0(orcid)0000-0002-5841-0462$$aSurra, J.C.$$uUniversidad de Zaragoza
000129998 700__ $$0(orcid)0000-0003-1197-4276$$aArnal, C.$$uUniversidad de Zaragoza
000129998 700__ $$0(orcid)0000-0002-3595-7668$$aRodríguez-Yoldi, M.J.$$uUniversidad de Zaragoza
000129998 700__ $$aAndrés-Lacueva, C.
000129998 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, J.$$uUniversidad de Zaragoza
000129998 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000129998 7102_ $$12008$$2640$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Nutrición Bromatología
000129998 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000129998 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000129998 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal
000129998 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000129998 773__ $$g64, 20 (2020), 2000354 [14 pp.]$$pMOL NUTR FOOD RES$$tMOLECULAR NUTRITION & FOOD RESEARCH$$x1613-4125
000129998 8564_ $$s609759$$uhttps://zaguan.unizar.es/record/129998/files/texto_completo.pdf$$yPostprint
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000129998 909CO $$ooai:zaguan.unizar.es:129998$$particulos$$pdriver
000129998 951__ $$a2024-01-18-09:04:57
000129998 980__ $$aARTICLE