000130011 001__ 130011
000130011 005__ 20240705134146.0
000130011 0247_ $$2doi$$a10.1186/s12933-023-02075-0
000130011 0248_ $$2sideral$$a136324
000130011 037__ $$aART-2023-136324
000130011 041__ $$aeng
000130011 100__ $$aLopez-Yus, Marta
000130011 245__ $$aIsthmin-1 (ISM1), a novel adipokine that reflects abdominal adipose tissue distribution in individuals with obesity
000130011 260__ $$c2023
000130011 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130011 5203_ $$aBackground: The assessment of obesity-related health risks has traditionally relied on the Body Mass Index and waist circumference, but their limitations have propelled the need for a more comprehensive approach. The differentiation between visceral (VIS) and subcutaneous (SC) fat provides a finer-grained understanding of these risks, yet practical assessment methods are lacking. We hypothesized that combining the SC-VIS fat ratio with non-invasive biomarkers could create a valuable tool for obesity-related risk assessment.
Methods and results: A clinical study of 125 individuals with obesity revealed significant differences in abdominal fat distribution measured by CT-scan among genders and distinct models of obesity, including visceral, subcutaneous, and the SC/VIS ratio. Stratification based on these models highlighted various metabolic changes. The SC/VIS ratio emerged as an excellent metric to differentiate metabolic status. Gene expression analysis identified candidate biomarkers, with ISM1 showing promise. Subsequent validation demonstrated a correlation between ISM1 levels in SC and plasma, reinforcing its potential as a non-invasive biomarker for fat distribution. Serum adipokine levels also correlated with the SC/VIS ratio. The Receiver Operating Characteristic analysis revealed ISM1’s efficacy in discriminating individuals with favorable metabolic profiles based on adipose tissue distribution. Correlation analysis also suggested that ISM1 was involved in glucose regulation pathways.
Conclusion: The study’s results support the hypothesis that the SC-VIS fat ratio and its derived non-invasive biomarkers can comprehensively assess obesity-related health risks. ISM1 could predict abdominal fat partitioning and be a potential biomarker for evaluating obesity-related health risks.
000130011 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B03-23R$$9info:eu-repo/grantAgreement/ES/ISCIII/PI22-01366
000130011 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000130011 592__ $$a2.621$$b2023
000130011 593__ $$aCardiology and Cardiovascular Medicine$$c2023$$dQ1
000130011 593__ $$aInternal Medicine$$c2023$$dQ1
000130011 593__ $$aEndocrinology, Diabetes and Metabolism$$c2023$$dQ1
000130011 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130011 700__ $$aCasamayor, Carmen$$uUniversidad de Zaragoza
000130011 700__ $$aSoriano-Godes, Juan Jose
000130011 700__ $$aBorlan, Sofia
000130011 700__ $$aGonzalez-Irazabal, Yolanda
000130011 700__ $$aGarcia-Sobreviela, Maria Pilar
000130011 700__ $$aGarcia-Rodriguez, Beatriz
000130011 700__ $$adel Moral-Bergos, Raquel
000130011 700__ $$aCalmarza, Pilar
000130011 700__ $$aArtigas, Jose Maria
000130011 700__ $$0(orcid)0000-0002-1033-6152$$aLorente-Cebrian, Silvia$$uUniversidad de Zaragoza
000130011 700__ $$aBernal-Monterde, Vanesa$$uUniversidad de Zaragoza
000130011 700__ $$0(orcid)0000-0002-7758-3588$$aSanz-Paris, Alejandro$$uUniversidad de Zaragoza
000130011 700__ $$aArbones-Mainar, Jose M.
000130011 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000130011 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000130011 7102_ $$11013$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Cirugía
000130011 773__ $$g22 (2023), 335 [12 pp.]$$pCardiovascular Diabetology$$tCardiovascular Diabetology$$x1475-2840
000130011 8564_ $$s1946392$$uhttps://zaguan.unizar.es/record/130011/files/texto_completo.pdf$$yVersión publicada
000130011 8564_ $$s2091152$$uhttps://zaguan.unizar.es/record/130011/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130011 909CO $$ooai:zaguan.unizar.es:130011$$particulos$$pdriver
000130011 951__ $$a2024-07-05-12:47:27
000130011 980__ $$aARTICLE