130047 20240118092027.0 doi 10.3390/ijms14047716 sideral 81812 ART-2013-81812 eng Martínez-Beamonte, R. Universidad de Zaragoza (orcid)0000-0002-8100-5596 Sphingomyelin in High-Density Lipoproteins: Structural Role and Biological Function 2013 High-density lipoprotein (HDL) levels are an inverse risk factor for cardiovascular diseases, and sphingomyelin (SM) is the second most abundant phospholipid component and the major sphingolipid in HDL. Considering the marked presence of SM, the present review has focused on the current knowledge about this phospholipid by addressing its variable distribution among HDL lipoparticles, how they acquire this phospholipid, and the important role that SM plays in regulating their fluidity and cholesterol efflux from different cells. In addition, plasma enzymes involved in HDL metabolism such as lecithin–cholesterol acyltransferase or phospholipid transfer protein are inhibited by HDL SM content. Likewise, HDL SM levels are influenced by dietary maneuvers (source of protein or fat), drugs (statins or diuretics) and modified in diseases such as diabetes, renal failure or Niemann–Pick disease. Furthermore, increased levels of HDL SM have been shown to be an inverse risk factor for coronary heart disease. The complexity of SM species, described using new lipidomic methodologies, and their distribution in different HDL particles under many experimental conditions are promising avenues for further research in the future. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/CICYT-FEDER/SAF 2010-14958 info:eu-repo/grantAgreement/ES/DGA-FSE/B69 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 2.339 2013 CHEMISTRY, MULTIDISCIPLINARY 52 / 145 = 0.359 2013 Q2 T2 info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Lou-Bonafonte, J. Universidad de Zaragoza (orcid)0000-0001-9578-6525 Martínez-Gracia, M. V. Osada, J. Universidad de Zaragoza (orcid)0000-0002-8251-8457 1005 410 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Fisiología 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 14, 4 (2013), 7716-7741 Int. j. mol. sci. International Journal of Molecular Sciences 1661-6596 820463 http://zaguan.unizar.es/record/130047/files/texto_completo.pdf Versión publicada 1999264 http://zaguan.unizar.es/record/130047/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130047 articulos driver 2024-01-18-09:06:58 ARTICLE