000130050 001__ 130050
000130050 005__ 20241125101150.0
000130050 0247_ $$2doi$$a10.1109/JBHI.2023.3297550
000130050 0248_ $$2sideral$$a136337
000130050 037__ $$aART-2023-136337
000130050 041__ $$aeng
000130050 100__ $$aBueno-Palomeque, Freddy L.
000130050 245__ $$aQRS-T angles as markers for heart sphericity in subjects with intrauterine growth restriction: a simulation study
000130050 260__ $$c2023
000130050 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130050 5203_ $$aChanges induced by intrauterine growth restriction (IUGR) in cardiovascular anatomy and function that persist throughout life have been associated with a higher predisposition to heart disease in adulthood. Together with cardiac morphological remodelling, evaluated through the ventricular sphericity index, alterations in cardiac electrical function have been reported by characterization of the depolarization and repolarization loops, and their angular relationship, measured from the vectorcardiogram. The underlying relationship between the morphological remodelling and the angular variation of QRS and T-wave dominant vectors, if any, has not been explored. The aim of this study was to evaluate this relationship using computational models based on realistic heart and torso in which IUGR-induced morphological changes were incorporated by reducing the ventricular sphericity index. Specifically, we departed from a control model and we built eight different globular heart models by reducing the base-to-apex length and enlarging the basal ventricular diameter. We computed QRS and T-wave dominant vectors and angles from simulated pseudo-electrocardiograms and we compared them with clinical measurements. Results for the QRS to T angles follow a change trend congruent with that reported in clinical data, supporting the hypothesis that the IUGR-induced morphological remodelling could contribute to explain the observed angle changes in IUGR patients. By additionally varying the position of the ventricles with respect to the torso and the electrodes, we found that electrode displacement can impact the quantified angles and should be considered when interpreting the results.
000130050 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2020-119457GB-I00$$9info:eu-repo/grantAgreement/ES/AEI/PID2021-128972OA-I00$$9info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R$$9info:eu-repo/grantAgreement/ES/DGA/LMP94_21$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/RYC2019-027420-I$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00
000130050 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000130050 590__ $$a6.7$$b2023
000130050 592__ $$a1.964$$b2023
000130050 591__ $$aCOMPUTER SCIENCE, INFORMATION SYSTEMS$$b26 / 250 = 0.104$$c2023$$dQ1$$eT1
000130050 591__ $$aMATHEMATICAL & COMPUTATIONAL BIOLOGY$$b5 / 66 = 0.076$$c2023$$dQ1$$eT1
000130050 591__ $$aMEDICAL INFORMATICS$$b3 / 44 = 0.068$$c2023$$dQ1$$eT1
000130050 591__ $$aCOMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS$$b21 / 170 = 0.124$$c2023$$dQ1$$eT1
000130050 593__ $$aElectrical and Electronic Engineering$$c2023$$dQ1
000130050 593__ $$aBiotechnology$$c2023$$dQ1
000130050 593__ $$aHealth Information Management$$c2023$$dQ1
000130050 593__ $$aHealth Informatics$$c2023$$dQ1
000130050 593__ $$aComputer Science Applications$$c2023$$dQ1
000130050 594__ $$a13.6$$b2023
000130050 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130050 700__ $$aMountris, Konstantinos A.
000130050 700__ $$aOrtigosa, Nuria
000130050 700__ $$0(orcid)0000-0003-1272-0550$$aBailón, Raquel$$uUniversidad de Zaragoza
000130050 700__ $$aBijnens, Bart
000130050 700__ $$aCrispi, Fàtima
000130050 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, Esther$$uUniversidad de Zaragoza
000130050 700__ $$0(orcid)0000-0003-3183-4107$$aMincholé, Ana$$uUniversidad de Zaragoza
000130050 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, Pablo$$uUniversidad de Zaragoza
000130050 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000130050 773__ $$g27, 10 (2023), 4707-4718$$pIEEE j. biomed. health inform.$$tIEEE journal of biomedical and health informatics$$x2168-2194
000130050 8564_ $$s4617608$$uhttps://zaguan.unizar.es/record/130050/files/texto_completo.pdf$$yVersión publicada
000130050 8564_ $$s3783460$$uhttps://zaguan.unizar.es/record/130050/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130050 909CO $$ooai:zaguan.unizar.es:130050$$particulos$$pdriver
000130050 951__ $$a2024-11-22-12:06:35
000130050 980__ $$aARTICLE