000130052 001__ 130052
000130052 005__ 20241125101150.0
000130052 0247_ $$2doi$$a10.1109/JBHI.2023.3310878
000130052 0248_ $$2sideral$$a136351
000130052 037__ $$aART-2023-136351
000130052 041__ $$aeng
000130052 100__ $$aGómez, Neurys$$uUniversidad de Zaragoza
000130052 245__ $$aTime-warping analysis of the T-wave peak-to-end Interval to quantify ventricular repolarization dispersion during ischemia
000130052 260__ $$c2023
000130052 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130052 5203_ $$aVariations in the dispersion of ventricular repolarization can be quantified by T-wave time-warping based index, dw . However, the early phase of the T-wave can be affected by ST-segment changes during ischemia. We hypothesized that restricting dw to the T-wave peak-to-end ( Tpe ) would circumvent this limitation while still quantifying variations in repolarization dispersion. A total of 101 ECG recordings from patients undergoing coronary occlusion, together with their control recordings, were analyzed. A series of dw values was calculated by quantifying the Tpe morphological variations between the T-waves at different occlusion stages and a baseline T-wave. We introduced a normalized version of dw , Rd , reflecting variations of dw during occlusion relative to control recordings ( Rd=1 corresponds to the same level of variation). The dw series followed a gradually increasing trend with occlusion time, reaching median [range] Rd values of 9.44 [1.01, 80.74] at the occlusion end. Rd at occlusion end was significantly higher than threshold values of 1, 2, 5, and 10 in 94.1%, 85.11%, 64.4% and 48.5% of patients, respectively. The spatial lead-wise analysis of dw showed distinct distributions depending on the occluded artery, suggesting a relation with the ischemia location. The relative variation R with ischemia of index dw (9.4) is greater than that of the T-wave amplitude (7.7), Tpe interval (2.7) and T-wave width (3.0). In conclusion, dw tracks ischemic-induced variations in repolarization dispersion in a more robust manner than classical indexes, avoiding the impact of ST segment elevation/depression or early T-wave distortions, thus warranting further clinical studies.
000130052 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2021-128972OA-I00$$9info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-104881RB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/RYC2021-031413-I$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00
000130052 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130052 590__ $$a6.7$$b2023
000130052 592__ $$a1.964$$b2023
000130052 591__ $$aCOMPUTER SCIENCE, INFORMATION SYSTEMS$$b26 / 250 = 0.104$$c2023$$dQ1$$eT1
000130052 591__ $$aMATHEMATICAL & COMPUTATIONAL BIOLOGY$$b5 / 66 = 0.076$$c2023$$dQ1$$eT1
000130052 591__ $$aMEDICAL INFORMATICS$$b3 / 44 = 0.068$$c2023$$dQ1$$eT1
000130052 591__ $$aCOMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS$$b21 / 170 = 0.124$$c2023$$dQ1$$eT1
000130052 593__ $$aElectrical and Electronic Engineering$$c2023$$dQ1
000130052 593__ $$aBiotechnology$$c2023$$dQ1
000130052 593__ $$aHealth Information Management$$c2023$$dQ1
000130052 593__ $$aHealth Informatics$$c2023$$dQ1
000130052 593__ $$aComputer Science Applications$$c2023$$dQ1
000130052 594__ $$a13.6$$b2023
000130052 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000130052 700__ $$0(orcid)0000-0003-4130-5866$$aRamírez, Julia$$uUniversidad de Zaragoza
000130052 700__ $$0(orcid)0000-0002-7503-3339$$aMartínez, Juan Pablo$$uUniversidad de Zaragoza
000130052 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, Pablo$$uUniversidad de Zaragoza
000130052 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000130052 773__ $$g27, 11 (2023), 5314-5325$$pIEEE j. biomed. health inform.$$tIEEE journal of biomedical and health informatics$$x2168-2194
000130052 8564_ $$s984735$$uhttps://zaguan.unizar.es/record/130052/files/texto_completo.pdf$$yPostprint
000130052 8564_ $$s1501613$$uhttps://zaguan.unizar.es/record/130052/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000130052 909CO $$ooai:zaguan.unizar.es:130052$$particulos$$pdriver
000130052 951__ $$a2024-11-22-12:06:36
000130052 980__ $$aARTICLE