000130059 001__ 130059 000130059 005__ 20240122171020.0 000130059 0247_ $$2doi$$a10.1183/13993003.00234-2016 000130059 0248_ $$2sideral$$a96693 000130059 037__ $$aART-2016-96693 000130059 041__ $$aeng 000130059 100__ $$0(orcid)0000-0001-6724-5158$$aVicente, E.$$uUniversidad de Zaragoza 000130059 245__ $$aUpper airway and systemic inflammation in obstructive sleep apnoea 000130059 260__ $$c2016 000130059 5060_ $$aAccess copy available to the general public$$fUnrestricted 000130059 5203_ $$aObstructive sleep apnoea (OSA) is associated with pharyngeal inflammation, but the coexistence of systemic inflammation is controversial. This study investigated whether local and systemic inflammatory biomarkers are related in patients with OSA. An uncontrolled extension to the study assessed the response to effective treatment. We recruited 89 patients with OSA (apnoea/hypopnoea index (AHI) =5 events · h-1), 28 snorers and 26 healthy controls. Pharyngeal lavage (PHAL) and plasma samples were collected at baseline and after a 1-year follow-up. Inflammatory cells were evaluated by flow cytometry; interleukin (IL)-6, IL-8 and tumour necrosis factor-a were evaluated by immunoassay. In PHAL, CD4+ T-cells, IL-6 and IL-8 were higher in OSA patients than in snorers or healthy controls ( p<0.05). The AHI correlated with CD4+, IL-6 and IL-8 in PHAL (all p-values <0.05). There were no differences in the inflammatory biomarkers in plasma between the study groups and no relationship between plasma and PHAL biomarkers. Biomarkers decreased significantly in PHAL but not in plasma after 1 year of therapy with continuous positive airway pressure or surgery. In patients with OSA, increased levels of inflammatory biomarkers were found in PHAL, which were reduced with effective treatment. No simultaneous increase in plasma inflammatory biomarkers was found. Copyright 000130059 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI10-02696 000130059 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000130059 590__ $$a10.569$$b2016 000130059 591__ $$aRESPIRATORY SYSTEM$$b3 / 59 = 0.051$$c2016$$dQ1$$eT1 000130059 592__ $$a3.508$$b2016 000130059 593__ $$aPulmonary and Respiratory Medicine$$c2016$$dQ1 000130059 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1 000130059 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000130059 700__ $$aMarin, J. M. 000130059 700__ $$aCarrizo, S. J. 000130059 700__ $$aOsuna, C. S. 000130059 700__ $$aGonzález, R. 000130059 700__ $$aMarin-Oto, M. 000130059 700__ $$aForner, M. 000130059 700__ $$aVicente, P. 000130059 700__ $$aCubero, P. 000130059 700__ $$aGil, A. V. 000130059 700__ $$aSoler, X. 000130059 7102_ $$11004$$2653$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Otorrinolaringología 000130059 773__ $$g48, 4 (2016), 1108-1117$$pEur. respir. j.$$tEuropean respiratory journal$$x0903-1936 000130059 8564_ $$s450761$$uhttps://zaguan.unizar.es/record/130059/files/texto_completo.pdf$$yPostprint 000130059 8564_ $$s1719423$$uhttps://zaguan.unizar.es/record/130059/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000130059 909CO $$ooai:zaguan.unizar.es:130059$$particulos$$pdriver 000130059 951__ $$a2024-01-22-15:23:31 000130059 980__ $$aARTICLE