000130065 001__ 130065 000130065 005__ 20240122171020.0 000130065 0247_ $$2doi$$a10.1186/s40248-019-0186-3 000130065 0248_ $$2sideral$$a115941 000130065 037__ $$aART-2019-115941 000130065 041__ $$aeng 000130065 100__ $$aMarin-Oto, M. 000130065 245__ $$aLong term management of obstructive sleep apnea and its comorbidities 000130065 260__ $$c2019 000130065 5060_ $$aAccess copy available to the general public$$fUnrestricted 000130065 5203_ $$aObstructive sleep apnea (OSA) is a worldwide highly prevalent disease associated with systemic consequences, including excessive sleepiness, impairment of neurocognitive function and daytime performance, including driving ability. The long-term sequelae of OSA include and increase risk for cardiovascular, cerebrovascular and metabolic syndrome disorders that ultimately lead to premature death if untreated. To ensure optimal long-term outcomes, the assessment and management of OSA should be personalized with the involvement of the appropriate specialist. Most studies have demonstrated inmediate improvement in daytime somnolence and quality of life with CPAP and other therapies, but the effect of long-term treatment on mortality is still under debate. Currently, the long-term management of OSA should be based on a) identifying physiological or structural abnormalities that are treatable at the time of patient evaluation and b) comprehensive lifestyle interventions, especially weight-loss interventions, which are associated with improvements in OSA severity, cardiometabolic comorbidities, and quality of life. In long-term management, attention should be paid to the clinical changes related to a potential reoccurrence of OSA symptoms and it is also necessary to monitor throughout the follow up how the main associated comorbidities evolve. 000130065 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER-FIS/PI18-01524 000130065 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000130065 592__ $$a0.609$$b2019 000130065 593__ $$aPulmonary and Respiratory Medicine$$c2019$$dQ2 000130065 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion 000130065 700__ $$0(orcid)0000-0001-6724-5158$$aVicente, E.E.$$uUniversidad de Zaragoza 000130065 700__ $$0(orcid)0000-0001-9096-2294$$aMarin, J.M.$$uUniversidad de Zaragoza 000130065 7102_ $$11004$$2653$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Otorrinolaringología 000130065 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000130065 773__ $$g14, 1 (2019), 21 [9 pp]$$pMultidisciplinary Respiratory Medicine$$tMultidisciplinary Respiratory Medicine$$x1828-695X 000130065 8564_ $$s941947$$uhttps://zaguan.unizar.es/record/130065/files/texto_completo.pdf$$yVersión publicada 000130065 8564_ $$s2707625$$uhttps://zaguan.unizar.es/record/130065/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000130065 909CO $$ooai:zaguan.unizar.es:130065$$particulos$$pdriver 000130065 951__ $$a2024-01-22-15:24:41 000130065 980__ $$aARTICLE