000130104 001__ 130104
000130104 005__ 20240122171020.0
000130104 0247_ $$2doi$$a10.1164/rccm.201801-0119OC
000130104 0248_ $$2sideral$$a136501
000130104 037__ $$aART-2019-136501
000130104 041__ $$aeng
000130104 100__ $$aWu, Benjamin G.
000130104 245__ $$aSevere obstructive sleep apnea is associated with alterations in the nasal microbiome and an increase in inflammation
000130104 260__ $$c2019
000130104 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130104 5203_ $$aRationale: Obstructive sleep apnea (OSA) is associated with recurrent obstruction, subepithelial edema, and airway inflammation. The resultant inflammation may influence or be influenced by the nasal microbiome.
Objectives: To evaluate whether the composition of the nasal microbiota is associated with obstructive sleep apnea and inflammatory biomarkers.
Methods: Two large cohorts were used: 1) a discovery cohort of 472 subjects from the WTCSNORE (Seated, Supine and Post-Decongestion Nasal Resistance in World Trade Center Rescue and Recovery Workers) cohort, and 2) a validation cohort of 93 subjects rom the Zaragoza Sleep cohort. Sleep apnea was diagnosed using home sleep tests. Nasal lavages were obtained from cohort subjects to measure: 1) microbiome composition (based on 16S rRNA gene sequencing), and 2) biomarkers for inflammation (inflammatory cells, IL-8, and IL-6). Longitudinal 3-month samples were obtained in the validation cohort, including after continuous positive airway pressure treatment when indicated.
Measurements and Main Results: In both cohorts, we identified that: 1) severity of OSA correlated with differences in microbiome diversity and composition; 2) the nasal microbiome of subjects with severe OSA were enriched with Streptococcus, Prevotella, and Veillonella; and 3) the nasal microbiome differences were associated with inflammatory biomarkers. Network analysis identified clusters of cooccurring microbes that defined communities. Several common oral commensals (e.g., Streptococcus, Rothia, Veillonella, and Fusobacterium) correlated with apnea–hypopnea index. Three months of treatment with continuous positive airway pressure did not change the composition of the nasal microbiota.
Conclusions: We demonstrate that the presence of an altered microbiome in severe OSA is associated with inflammatory markers. Further experimental approaches to explore causal links are needed.
000130104 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130104 590__ $$a17.452$$b2019
000130104 591__ $$aRESPIRATORY SYSTEM$$b2 / 64 = 0.031$$c2019$$dQ1$$eT1
000130104 591__ $$aCRITICAL CARE MEDICINE$$b3 / 36 = 0.083$$c2019$$dQ1$$eT1
000130104 592__ $$a5.882$$b2019
000130104 593__ $$aPulmonary and Respiratory Medicine$$c2019$$dQ1
000130104 593__ $$aCritical Care and Intensive Care Medicine$$c2019$$dQ1
000130104 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000130104 700__ $$aSulaiman, Imran
000130104 700__ $$aWang, Jing
000130104 700__ $$aShen, Nan
000130104 700__ $$aClemente, Jose C.
000130104 700__ $$aLi, Yonghua
000130104 700__ $$aLaumbach, Robert J.
000130104 700__ $$aLu, Shou-En
000130104 700__ $$aUdasin, Iris
000130104 700__ $$aLe-Hoang, Oanh
000130104 700__ $$aPerez, Alan
000130104 700__ $$aAlimokhtari, Shahnaz
000130104 700__ $$aBlack, Kathleen
000130104 700__ $$aPlietz, Michael
000130104 700__ $$aTwumasi, Akosua
000130104 700__ $$aSanders, Haley
000130104 700__ $$aMalecha, Patrick
000130104 700__ $$aKapoor, Bianca
000130104 700__ $$aScaglione, Benjamin D.
000130104 700__ $$aWang, Anbang
000130104 700__ $$aBlazoski, Cameron
000130104 700__ $$aWeiden, Michael D.
000130104 700__ $$aRapoport, David M.
000130104 700__ $$aHarrison, Denise
000130104 700__ $$aChitkara, Nishay
000130104 700__ $$0(orcid)0000-0001-6724-5158$$aVicente, Eugenio$$uUniversidad de Zaragoza
000130104 700__ $$aMarin, José M.
000130104 700__ $$aSunderram, Jag
000130104 700__ $$aAyappa, Indu
000130104 700__ $$aSegal, Leopoldo N.
000130104 7102_ $$11004$$2653$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Otorrinolaringología
000130104 773__ $$g199, 1 (2019), 99-109$$pAm. j. respir. crit. care med.$$tAmerican Journal of Respiratory and Critical Care Medicine$$x1073-449X
000130104 8564_ $$s1794291$$uhttps://zaguan.unizar.es/record/130104/files/texto_completo.pdf$$yPostprint
000130104 8564_ $$s2934276$$uhttps://zaguan.unizar.es/record/130104/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000130104 909CO $$ooai:zaguan.unizar.es:130104$$particulos$$pdriver
000130104 951__ $$a2024-01-22-15:27:20
000130104 980__ $$aARTICLE