000130109 001__ 130109
000130109 005__ 20241125101136.0
000130109 0247_ $$2doi$$a10.1002/2211-5463.13742
000130109 0248_ $$2sideral$$a136485
000130109 037__ $$aART-2023-136485
000130109 041__ $$aeng
000130109 100__ $$aGonzález, Cristina
000130109 245__ $$aDysfunction of Drosophila mitochondrial carrier homolog (Mtch) alters apoptosis and disturbs development
000130109 260__ $$c2023
000130109 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130109 5203_ $$aMitochondrial carrier homologs 1 (MTCH1) and 2 (MTCH2) are orphan members of the mitochondrial transporter family SLC25. Human MTCH1 is also known as presenilin 1‐associated protein, PSAP. MTCH2 is a receptor for tBid and is related to lipid metabolism. Both proteins have been recently described as protein insertases of the outer mitochondrial membrane. We have depleted Mtch in Drosophila and show here that mutant flies are unable to complete development, showing an excess of apoptosis during pupation; this observation was confirmed by RNAi in Schneider cells. These findings are contrary to what has been described in humans. We discuss the implications in view of recent reports concerning the function of these proteins.
000130109 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/BFU2009-11800$$9info:eu-repo/grantAgreement/ES/MINECO/RYC-2011-08363$$9info:eu-repo/grantAgreement/ES/UZ/UZ2010-BIO-03
000130109 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000130109 590__ $$a2.8$$b2023
000130109 592__ $$a0.789$$b2023
000130109 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b184 / 313 = 0.588$$c2023$$dQ3$$eT2
000130109 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2023$$dQ2
000130109 594__ $$a5.1$$b2023
000130109 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130109 700__ $$aMartínez-Sánchez, Lidia
000130109 700__ $$aClemente, Paula
000130109 700__ $$0(orcid)0000-0002-7243-1737$$aToivonen, Janne Markus$$uUniversidad de Zaragoza
000130109 700__ $$aArredondo, Juan José
000130109 700__ $$aFernández-Moreno, Miguel Ángel
000130109 700__ $$0(orcid)0000-0003-0062-1029$$aCarrodeguas, José Alberto$$uUniversidad de Zaragoza
000130109 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000130109 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular
000130109 773__ $$g14, 2 (2023), 276-289$$pFEBS openbio$$tFEBS openbio$$x2211-5463
000130109 8564_ $$s2124235$$uhttps://zaguan.unizar.es/record/130109/files/texto_completo.pdf$$yVersión publicada
000130109 8564_ $$s2098925$$uhttps://zaguan.unizar.es/record/130109/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130109 909CO $$ooai:zaguan.unizar.es:130109$$particulos$$pdriver
000130109 951__ $$a2024-11-22-12:00:47
000130109 980__ $$aARTICLE