130109 20241125101136.0 doi 10.1002/2211-5463.13742 sideral 136485 ART-2023-136485 eng González, Cristina Dysfunction of Drosophila mitochondrial carrier homolog (Mtch) alters apoptosis and disturbs development 2023 Access copy available to the general public Unrestricted Mitochondrial carrier homologs 1 (MTCH1) and 2 (MTCH2) are orphan members of the mitochondrial transporter family SLC25. Human MTCH1 is also known as presenilin 1‐associated protein, PSAP. MTCH2 is a receptor for tBid and is related to lipid metabolism. Both proteins have been recently described as protein insertases of the outer mitochondrial membrane. We have depleted Mtch in Drosophila and show here that mutant flies are unable to complete development, showing an excess of apoptosis during pupation; this observation was confirmed by RNAi in Schneider cells. These findings are contrary to what has been described in humans. We discuss the implications in view of recent reports concerning the function of these proteins. info:eu-repo/grantAgreement/ES/MICINN/BFU2009-11800 info:eu-repo/grantAgreement/ES/MINECO/RYC-2011-08363 info:eu-repo/grantAgreement/ES/UZ/UZ2010-BIO-03 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 2.8 2023 BIOCHEMISTRY & MOLECULAR BIOLOGY 184 / 313 = 0.588 2023 Q3 T2 0.789 2023 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2023 Q2 5.1 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Martínez-Sánchez, Lidia Clemente, Paula Toivonen, Janne Markus Universidad de Zaragoza (orcid)0000-0002-7243-1737 Arredondo, Juan José Fernández-Moreno, Miguel Ángel Carrodeguas, José Alberto Universidad de Zaragoza (orcid)0000-0003-0062-1029 1001 420 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Genética 1002 050 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Biología Celular 14, 2 (2023), 276-289 FEBS openbio FEBS openbio 2211-5463 2124235 http://zaguan.unizar.es/record/130109/files/texto_completo.pdf Versión publicada 2098925 http://zaguan.unizar.es/record/130109/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130109 articulos driver 2024-11-22-12:00:47 ARTICLE