doi:10.1002/alz.12962engGong, JessicaHarris, KatieLipnicki, Darren M.Castro-Costa, EricoLima-Costa, Maria FernandaDiniz, Breno S.Xiao, ShifuLipton, Richard B.Katz, Mindy J.Wang, CuilingPreux, Pierre-MarieGuerchet, MaëlennGbessemehlan, AntoineRitchie, KarenAncelin, Marie-LaureSkoog, IngmarNajar, JennaSterner, Therese RydbergScarmeas, NikolaosYannakoulia, MaryKosmidis, Mary H.Guaita, AntonioRolandi, ElenaDavin, AnnalisaGureje, OyeTrompet, StellaGussekloo, JacobijnRiedel-Heller, SteffiPabst, AlexanderRöhr, SusanneShahar, SuzanaSingh, Devinder Kaur AjitRivan, Nurul Fatin Malekvan Boxtel, MartinKöhler, SebastianGanguli, MaryChang, Chung-ChouJacobsen, ErinHaan, MaryDing, DingZhao, QianhuaXiao, ZhenxuNarazaki, KenjiChen, TaoChen, SanmeiNg, Tze PinGwee, XinyiNumbers, KatyaMather, Karen A.Scazufca, MarciaLobo, AntonioDe-la-Cámara, ConcepciónLobo, ElenaSachdev, Perminder S.Brodaty, HenryHackett, Maree L.Peters, Sanne A. E.Woodward, MarkSex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortiumART-2023-132786Introduction Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. Methods A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. Results Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. Discussion Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.2023http://zaguan.unizar.es/record/13016210.1002/alz.12962http://zaguan.unizar.es/record/130162oai:zaguan.unizar.es:130162info:eu-repo/grantAgreement/ES/DGA-FEDER/B15-17Rinfo:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/19-01874info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321Einfo:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103Alzheimers & Dementia 19, 8 (2023), 3365-3378byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess