130162 20241125101128.0 doi 10.1002/alz.12962 sideral 132786 ART-2023-132786 eng Gong, Jessica Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium 2023 Access copy available to the general public Unrestricted Introduction Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. Methods A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. Results Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. Discussion Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men. info:eu-repo/grantAgreement/ES/DGA-FEDER/B15-17R info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/19-01874 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 13.1 2023 CLINICAL NEUROLOGY 5 / 280 = 0.018 2023 Q1 T1 3.226 2023 Epidemiology 2023 Q1 Cellular and Molecular Neuroscience 2023 Q1 Developmental Neuroscience 2023 Q1 Psychiatry and Mental Health 2023 Q1 Health Policy 2023 Q1 Neurology (clinical) 2023 Q1 Geriatrics and Gerontology 2023 Q1 14.5 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Harris, Katie Lipnicki, Darren M. Castro-Costa, Erico Lima-Costa, Maria Fernanda Diniz, Breno S. Xiao, Shifu Lipton, Richard B. Katz, Mindy J. Wang, Cuiling Preux, Pierre-Marie Guerchet, Maëlenn Gbessemehlan, Antoine Ritchie, Karen Ancelin, Marie-Laure Skoog, Ingmar Najar, Jenna Sterner, Therese Rydberg Scarmeas, Nikolaos Yannakoulia, Mary Kosmidis, Mary H. Guaita, Antonio Rolandi, Elena Davin, Annalisa Gureje, Oye Trompet, Stella Gussekloo, Jacobijn Riedel-Heller, Steffi Pabst, Alexander Röhr, Susanne Shahar, Suzana Singh, Devinder Kaur Ajit Rivan, Nurul Fatin Malek van Boxtel, Martin Köhler, Sebastian Ganguli, Mary Chang, Chung-Chou Jacobsen, Erin Haan, Mary Ding, Ding Zhao, Qianhua Xiao, Zhenxu Narazaki, Kenji Chen, Tao Chen, Sanmei Ng, Tze Pin Gwee, Xinyi Numbers, Katya Mather, Karen A. Scazufca, Marcia Lobo, Antonio Universidad de Zaragoza (orcid)0000-0002-9098-655X De-la-Cámara, Concepción Universidad de Zaragoza (orcid)0000-0003-2284-7862 Lobo, Elena Universidad de Zaragoza (orcid)0000-0002-1252-2397 Sachdev, Perminder S. Brodaty, Henry Hackett, Maree L. Peters, Sanne A. E. Woodward, Mark 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 19, 8 (2023), 3365-3378 Alzheimers & Dementia Alzheimers & Dementia 1552-5260 1203728 http://zaguan.unizar.es/record/130162/files/texto_completo.pdf Versión publicada info:eu-repo/date/embargoEnd/2024-03-31 2295216 http://zaguan.unizar.es/record/130162/files/texto_completo.jpg?subformat=icon icon Versión publicada info:eu-repo/date/embargoEnd/2024-03-31 oai:zaguan.unizar.es:130162 articulos driver 2024-11-22-11:58:19 ARTICLE