130230 20241125101155.0 doi 10.1016/j.jmbbm.2023.105968 sideral 134633 ART-2023-134633 eng Henderson, Bradley S. Modeling fatigue failure in soft tissue using a visco-hyperelastic model with discontinuous damage 2023 Access copy available to the general public Unrestricted Soft tissue is susceptible to injury from single high-magnitude static loads and from repetitive low-magnitude fatigue loads. While many constitutive formulations have been developed and validated to model static failure in soft tissue, a modeling framework is not well-established for fatigue failure. Here we determined the feasibility of using a visco-hyperelastic damage model with discontinuous damage (strain energy-based damage criterion) to simulate low- and high-cycle fatigue failure in soft fibrous tissue. Cyclic creep data from six uniaxial tensile fatigue experiments of human medial meniscus were used to calibrate the specimen-specific material parameters. The model was able to successfully simulate all three characteristic stages of cyclic creep, and predict the number of cycles until tissue rupture. Mathematically, damage propagated under constant cyclic stress due to timedependent viscoelastic increases in tensile stretch that in turn increased strain energy. Our results implicate solid viscoelasticity as a fundamental regulator of fatigue failure in soft tissue, where tissue with slow stress relaxation times will be more resistant to fatigue injury. In a validation study, the visco-hyperelastic damage model was able to simulate characteristic stress-strain curves of pull to failure experiments (static failure) when using material parameters curve fit to the fatigue experiments. For the first time, we’ve shown that a viscohyperelastic discontinuous damage framework can model cyclic creep and predict material rupture in soft tissue, and may enable the reliable simulation of both fatigue and static failure behavior from a single constitutive formulation. info:eu-repo/semantics/embargoedAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.3 2023 ENGINEERING, BIOMEDICAL 53 / 123 = 0.431 2023 Q2 T2 MATERIALS SCIENCE, BIOMATERIALS 32 / 53 = 0.604 2023 Q3 T2 0.748 2023 Mechanics of Materials 2023 Q1 Biomaterials 2023 Q2 Biomedical Engineering 2023 Q2 7.2 2023 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Cudworth, Katelyn F. Peña, Estefanía Universidad de Zaragoza (orcid)0000-0002-0664-5024 Lujan, Trevor J. 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 144 (2023), 105968 [12 pp.] J. mech. behav. boomed. mater. Journal of the Mechanical Behavior of Biomedical Materials 1751-6161 338753 http://zaguan.unizar.es/record/130230/files/texto_completo.pdf Postprint info:eu-repo/date/embargoEnd/2025-06-08 804702 http://zaguan.unizar.es/record/130230/files/texto_completo.jpg?subformat=icon icon Postprint info:eu-repo/date/embargoEnd/2025-06-08 oai:zaguan.unizar.es:130230 articulos driver 2024-11-22-12:09:04 ARTICLE