000130248 001__ 130248 000130248 005__ 20240123131022.0 000130248 0247_ $$2doi$$a10.2741/756 000130248 0248_ $$2sideral$$a101405 000130248 037__ $$aART-2016-101405 000130248 041__ $$aeng 000130248 100__ $$aSancho-Knapik, S.$$uUniversidad de Zaragoza 000130248 245__ $$aDiet and sex hormones regulate hepatic Synaptotagmin 1 mRNA in mice 000130248 260__ $$c2016 000130248 5203_ $$aThe expression of Synaptotagmin 1 (Syt1) has been found to be associated with the lipid droplets in liver. Here, we studied the expression of Syt1 in Apoe-deficient mice receiving cholesterol, Western diet, squalene, and oleanolic acid. We also studied the influence of sex and impact of surgical castration. Dietary cholesterol increased hepatic Syt1 expression, an effect that was enhanced when cholesterol was combined with saturated fat present in a Western diet. This potentiation was modified by the administration of 10 mg/kg oleanolic acid or 1 g/kg squalene. Females fed chow or Western diet showed higher levels of hepatic Syt1 expression as compared to male mice on the same diet. Surgical castration of males did not modify the Syt1 expression; however, ovariectomy led to decreased levels. The data show that hepatic Syt1 expression is influenced by diet and hormonal milieu. 000130248 536__ $$9info:eu-repo/grantAgreement/ES/CICYT-FEDER/SAF 2010-14958$$9info:eu-repo/grantAgreement/ES/CICYT-FEDER/2013-41651-R$$9info:eu-repo/grantAgreement/ES/DGA-FSE/B69 000130248 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000130248 592__ $$a0.783$$b2016 000130248 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2016$$dQ2 000130248 593__ $$aMedicine (miscellaneous)$$c2016$$dQ2 000130248 593__ $$aImmunology and Microbiology (miscellaneous)$$c2016$$dQ3 000130248 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000130248 700__ $$0(orcid)0000-0002-2348-8702$$aGabas-Rivera, C. 000130248 700__ $$aGascon, S. 000130248 700__ $$aRomanos, E. 000130248 700__ $$0(orcid)0000-0002-8100-5596$$aMartinez-Beamonte, R.$$uUniversidad de Zaragoza 000130248 700__ $$0(orcid)0000-0002-0108-1004$$aNavarro, M.A.$$uUniversidad de Zaragoza 000130248 700__ $$0(orcid)0000-0002-5841-0462$$aSurra, J.C.$$uUniversidad de Zaragoza 000130248 700__ $$0(orcid)0000-0003-1197-4276$$aArnal, C.$$uUniversidad de Zaragoza 000130248 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, J.$$uUniversidad de Zaragoza 000130248 7102_ $$12008$$2640$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Nutrición Bromatología 000130248 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal 000130248 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal 000130248 7102_ $$12008$$2X$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cProy. investigación HTA 000130248 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole. 000130248 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular 000130248 773__ $$g8, 1 (2016), 129-142$$pFront. biosci. (Elite ed.)$$tFrontiers in bioscience (Elite edition)$$x1945-0494 000130248 8564_ $$s3526909$$uhttps://zaguan.unizar.es/record/130248/files/texto_completo.pdf$$yVersión publicada 000130248 8564_ $$s2181599$$uhttps://zaguan.unizar.es/record/130248/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000130248 909CO $$ooai:zaguan.unizar.es:130248$$particulos$$pdriver 000130248 951__ $$a2024-01-23-12:43:16 000130248 980__ $$aARTICLE