130248 20240123131022.0 doi 10.2741/756 sideral 101405 ART-2016-101405 eng Sancho-Knapik, S. Universidad de Zaragoza Diet and sex hormones regulate hepatic Synaptotagmin 1 mRNA in mice 2016 The expression of Synaptotagmin 1 (Syt1) has been found to be associated with the lipid droplets in liver. Here, we studied the expression of Syt1 in Apoe-deficient mice receiving cholesterol, Western diet, squalene, and oleanolic acid. We also studied the influence of sex and impact of surgical castration. Dietary cholesterol increased hepatic Syt1 expression, an effect that was enhanced when cholesterol was combined with saturated fat present in a Western diet. This potentiation was modified by the administration of 10 mg/kg oleanolic acid or 1 g/kg squalene. Females fed chow or Western diet showed higher levels of hepatic Syt1 expression as compared to male mice on the same diet. Surgical castration of males did not modify the Syt1 expression; however, ovariectomy led to decreased levels. The data show that hepatic Syt1 expression is influenced by diet and hormonal milieu. info:eu-repo/grantAgreement/ES/CICYT-FEDER/SAF 2010-14958 info:eu-repo/grantAgreement/ES/CICYT-FEDER/2013-41651-R info:eu-repo/grantAgreement/ES/DGA-FSE/B69 info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 0.783 2016 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2016 Q2 Medicine (miscellaneous) 2016 Q2 Immunology and Microbiology (miscellaneous) 2016 Q3 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gabas-Rivera, C. (orcid)0000-0002-2348-8702 Gascon, S. Romanos, E. Martinez-Beamonte, R. Universidad de Zaragoza (orcid)0000-0002-8100-5596 Navarro, M.A. Universidad de Zaragoza (orcid)0000-0002-0108-1004 Surra, J.C. Universidad de Zaragoza (orcid)0000-0002-5841-0462 Arnal, C. Universidad de Zaragoza (orcid)0000-0003-1197-4276 Osada, J. Universidad de Zaragoza (orcid)0000-0002-8251-8457 2008 640 Universidad de Zaragoza Dpto. Produc.Animal Cienc.Ali. Área Nutrición Bromatología 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 2008 700 Universidad de Zaragoza Dpto. Produc.Animal Cienc.Ali. Área Producción Animal 2008 X Universidad de Zaragoza Dpto. Produc.Animal Cienc.Ali. Proy. investigación HTA 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 1002 050 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Biología Celular 8, 1 (2016), 129-142 Front. biosci. (Elite ed.) Frontiers in bioscience (Elite edition) 1945-0494 3526909 http://zaguan.unizar.es/record/130248/files/texto_completo.pdf Versión publicada 2181599 http://zaguan.unizar.es/record/130248/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130248 articulos driver 2024-01-23-12:43:16 ARTICLE