000130255 001__ 130255
000130255 005__ 20240123131022.0
000130255 0247_ $$2doi$$a10.1007/s12192-013-0461-8
000130255 0248_ $$2sideral$$a83359
000130255 037__ $$aART-2014-83359
000130255 041__ $$aeng
000130255 100__ $$aLatorre, E.
000130255 245__ $$aTLR2, TLR3, and TLR4 activation specifically alters the oxidative status of intestinal epithelial cells
000130255 260__ $$c2014
000130255 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130255 5203_ $$aIntestinal inflammatory diseases are the result of multiple processes, including mucosal oxidative stress and perturbed homeostasis between commensal bacteria and mucosal immunity. Toll-like receptors (TLRs) recognize molecular-associated microorganisms' patterns and trigger innate immunity responses contributing to intestinal homeostasis and inflammatory responses. However, TLRs effects on redox balance in intestinal mucosa remain unknown. Therefore, the present study analyzes the effect of TLR2, TLR3, and TLR4 on both oxidative damage of lipids and proteins, and the activity of antioxidant enzymes in enterocyte-like Caco-2 cells. The results show that the activation of these TLRs increased lipid and protein oxidation levels; however, the effect on the antioxidant enzymes activity is different depending on the TLR activated. These results suggest that the activation of TLR2, TLR3, and TLR4 might affect intestinal inflammation by not only their inherent innate immunity responses, but also their pro-oxidative effects on intestinal epithelial cells.
000130255 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000130255 590__ $$a3.163$$b2014
000130255 591__ $$aCELL BIOLOGY$$b101 / 184 = 0.549$$c2014$$dQ3$$eT2
000130255 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000130255 700__ $$aMendoza, C.
000130255 700__ $$aLayunta, E.
000130255 700__ $$aAlcalde, A.I.
000130255 700__ $$aMesonero, J.E.
000130255 773__ $$g19 (2014), 289-293$$pCell stress chaperones$$tCELL STRESS & CHAPERONES$$x1355-8145
000130255 8564_ $$s235502$$uhttps://zaguan.unizar.es/record/130255/files/texto_completo.pdf$$yPostprint
000130255 8564_ $$s773363$$uhttps://zaguan.unizar.es/record/130255/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000130255 909CO $$ooai:zaguan.unizar.es:130255$$particulos$$pdriver
000130255 951__ $$a2024-01-23-12:43:57
000130255 980__ $$aARTICLE