130255 20240123131022.0 doi 10.1007/s12192-013-0461-8 sideral 83359 ART-2014-83359 eng Latorre, E. TLR2, TLR3, and TLR4 activation specifically alters the oxidative status of intestinal epithelial cells 2014 Intestinal inflammatory diseases are the result of multiple processes, including mucosal oxidative stress and perturbed homeostasis between commensal bacteria and mucosal immunity. Toll-like receptors (TLRs) recognize molecular-associated microorganisms' patterns and trigger innate immunity responses contributing to intestinal homeostasis and inflammatory responses. However, TLRs effects on redox balance in intestinal mucosa remain unknown. Therefore, the present study analyzes the effect of TLR2, TLR3, and TLR4 on both oxidative damage of lipids and proteins, and the activity of antioxidant enzymes in enterocyte-like Caco-2 cells. The results show that the activation of these TLRs increased lipid and protein oxidation levels; however, the effect on the antioxidant enzymes activity is different depending on the TLR activated. These results suggest that the activation of TLR2, TLR3, and TLR4 might affect intestinal inflammation by not only their inherent innate immunity responses, but also their pro-oxidative effects on intestinal epithelial cells. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.163 2014 CELL BIOLOGY 101 / 184 = 0.549 2014 Q3 T2 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Mendoza, C. Layunta, E. Alcalde, A.I. Mesonero, J.E. 19 (2014), 289-293 Cell stress chaperones CELL STRESS & CHAPERONES 1355-8145 235502 http://zaguan.unizar.es/record/130255/files/texto_completo.pdf Postprint 773363 http://zaguan.unizar.es/record/130255/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:130255 articulos driver 2024-01-23-12:43:57 ARTICLE