000130264 001__ 130264
000130264 005__ 20240124152850.0
000130264 0247_ $$2doi$$a10.1097/TP.0000000000000050
000130264 0248_ $$2sideral$$a85812
000130264 037__ $$aART-2014-85812
000130264 041__ $$aeng
000130264 100__ $$aGarcía-Gil, Francisco A
000130264 245__ $$aEvaluation of Institut Georges Lopez-1 preservation solution in pig pancreas transplantation: a pilot study
000130264 260__ $$c2014
000130264 5203_ $$aBackground. Institut Georges Lopez-1 preservation solution (IGL-1) is an emerging extracellular-type electrolyte solution, low in viscosity, containing polyethylene glycol 35 as a colloid. Although IGL-1 has shown beneficial outcomes in kidney and liver preservation, this pilot study is the first to evaluate the efficacy of IGL-1 in pancreas transplantation (PT) compared with the University of Wisconsin solution (UW)
Methods. Sixteen Landrace pigs underwent allogeneic PT with 16 hr of cold ischemia. Grafts were preserved with IGL-1 (n=8) or UW (n=8). No immunosuppression was administered. We analyzed graft function, the acute-phase response, and oxidative stress in the pancreatic graft monitoring membrane fluidity and lipid peroxidation@@@Results. All eight grafts with IGL-1, but only six with UW, were functioning. Graft failures with UW resulted from graft thrombosis. There were no differences between the two solutions in the number of normoglycemic days (IGL-1: 11.5T6.2 versus UW: 8.5T4.4 days, P=0.1357), nor in lipid peroxidation during 16-hr cold ischemia (P=0.672), or reperfusion (P=0.185), but IGL-1 prevented changes in membrane fluidity after reperfusion when compared with UW (P=0.026)
Conclusion. IGL-1 offered the same degree of safety and effectiveness as UW in our model of pig PT with 16 hr of cold ischemia.
000130264 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/ISCIII-PI10-2877$$9info:eu-repo/grantAgreement/ES/MICINN/ISCIII-RD06-0013-1017
000130264 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130264 590__ $$a3.828$$b2014
000130264 591__ $$aSURGERY$$b17 / 196 = 0.087$$c2014$$dQ1$$eT1
000130264 591__ $$aTRANSPLANTATION$$b4 / 25 = 0.16$$c2014$$dQ1$$eT1
000130264 591__ $$aIMMUNOLOGY$$b43 / 147 = 0.293$$c2014$$dQ2$$eT1
000130264 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130264 700__ $$0(orcid)0000-0003-2656-6750$$aFuentes-Broto, Lorena$$uUniversidad de Zaragoza
000130264 700__ $$aAlbendea, Carlos D.
000130264 700__ $$0(orcid)0000-0002-7119-2244$$aSerrano, María Trinidad$$uUniversidad de Zaragoza
000130264 700__ $$aRoselló-Catafau, Joan
000130264 700__ $$aLampreave, Fermín
000130264 700__ $$aLópez-Pingarrón, Laura
000130264 700__ $$aEscartín, Jorge
000130264 700__ $$aSoria, Joaquín
000130264 700__ $$aGarcia, ,Joaquín J
000130264 700__ $$aFernández-Cruz, Laureano
000130264 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000130264 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000130264 773__ $$g97, 9 (2014), 901-907$$pTransplantation$$tTransplantation$$x0041-1337
000130264 8564_ $$s951700$$uhttps://zaguan.unizar.es/record/130264/files/texto_completo.pdf$$yVersión publicada
000130264 8564_ $$s2754260$$uhttps://zaguan.unizar.es/record/130264/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130264 909CO $$ooai:zaguan.unizar.es:130264$$particulos$$pdriver
000130264 951__ $$a2024-01-24-14:58:02
000130264 980__ $$aARTICLE