doi:10.1097/TP.0000000000000050engGarcía-Gil, Francisco AFuentes-Broto, LorenaAlbendea, Carlos D.Serrano, María TrinidadRoselló-Catafau, JoanLampreave, FermínLópez-Pingarrón, LauraEscartín, JorgeSoria, JoaquínGarcia, ,Joaquín JFernández-Cruz, LaureanoEvaluation of Institut Georges Lopez-1 preservation solution in pig pancreas transplantation: a pilot studyART-2014-85812Background. Institut Georges Lopez-1 preservation solution (IGL-1) is an emerging extracellular-type electrolyte solution, low in viscosity, containing polyethylene glycol 35 as a colloid. Although IGL-1 has shown beneficial outcomes in kidney and liver preservation, this pilot study is the first to evaluate the efficacy of IGL-1 in pancreas transplantation (PT) compared with the University of Wisconsin solution (UW) Methods. Sixteen Landrace pigs underwent allogeneic PT with 16 hr of cold ischemia. Grafts were preserved with IGL-1 (n=8) or UW (n=8). No immunosuppression was administered. We analyzed graft function, the acute-phase response, and oxidative stress in the pancreatic graft monitoring membrane fluidity and lipid peroxidation@@@Results. All eight grafts with IGL-1, but only six with UW, were functioning. Graft failures with UW resulted from graft thrombosis. There were no differences between the two solutions in the number of normoglycemic days (IGL-1: 11.5T6.2 versus UW: 8.5T4.4 days, P=0.1357), nor in lipid peroxidation during 16-hr cold ischemia (P=0.672), or reperfusion (P=0.185), but IGL-1 prevented changes in membrane fluidity after reperfusion when compared with UW (P=0.026) Conclusion. IGL-1 offered the same degree of safety and effectiveness as UW in our model of pig PT with 16 hr of cold ischemia.2014http://zaguan.unizar.es/record/13026410.1097/TP.0000000000000050http://zaguan.unizar.es/record/130264oai:zaguan.unizar.es:130264info:eu-repo/grantAgreement/ES/MICINN/ISCIII-PI10-2877info:eu-repo/grantAgreement/ES/MICINN/ISCIII-RD06-0013-1017Transplantation 97, 9 (2014), 901-907All rights reservedhttp://www.europeana.eu/rights/rr-f/info:eu-repo/semantics/closedAccess