130264 20240124152850.0 doi 10.1097/TP.0000000000000050 sideral 85812 ART-2014-85812 eng García-Gil, Francisco A Evaluation of Institut Georges Lopez-1 preservation solution in pig pancreas transplantation: a pilot study 2014 Background. Institut Georges Lopez-1 preservation solution (IGL-1) is an emerging extracellular-type electrolyte solution, low in viscosity, containing polyethylene glycol 35 as a colloid. Although IGL-1 has shown beneficial outcomes in kidney and liver preservation, this pilot study is the first to evaluate the efficacy of IGL-1 in pancreas transplantation (PT) compared with the University of Wisconsin solution (UW) Methods. Sixteen Landrace pigs underwent allogeneic PT with 16 hr of cold ischemia. Grafts were preserved with IGL-1 (n=8) or UW (n=8). No immunosuppression was administered. We analyzed graft function, the acute-phase response, and oxidative stress in the pancreatic graft monitoring membrane fluidity and lipid peroxidation@@@Results. All eight grafts with IGL-1, but only six with UW, were functioning. Graft failures with UW resulted from graft thrombosis. There were no differences between the two solutions in the number of normoglycemic days (IGL-1: 11.5T6.2 versus UW: 8.5T4.4 days, P=0.1357), nor in lipid peroxidation during 16-hr cold ischemia (P=0.672), or reperfusion (P=0.185), but IGL-1 prevented changes in membrane fluidity after reperfusion when compared with UW (P=0.026) Conclusion. IGL-1 offered the same degree of safety and effectiveness as UW in our model of pig PT with 16 hr of cold ischemia. info:eu-repo/grantAgreement/ES/MICINN/ISCIII-PI10-2877 info:eu-repo/grantAgreement/ES/MICINN/ISCIII-RD06-0013-1017 info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.828 2014 SURGERY 17 / 196 = 0.087 2014 Q1 T1 TRANSPLANTATION 4 / 25 = 0.16 2014 Q1 T1 IMMUNOLOGY 43 / 147 = 0.293 2014 Q2 T1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Fuentes-Broto, Lorena Universidad de Zaragoza (orcid)0000-0003-2656-6750 Albendea, Carlos D. Serrano, María Trinidad Universidad de Zaragoza (orcid)0000-0002-7119-2244 Roselló-Catafau, Joan Lampreave, Fermín López-Pingarrón, Laura Escartín, Jorge Soria, Joaquín Garcia, ,Joaquín J Fernández-Cruz, Laureano 1005 410 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Fisiología 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 97, 9 (2014), 901-907 Transplantation Transplantation 0041-1337 951700 http://zaguan.unizar.es/record/130264/files/texto_completo.pdf Versión publicada 2754260 http://zaguan.unizar.es/record/130264/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130264 articulos driver 2024-01-24-14:58:02 ARTICLE