130271 20240124152850.0 doi 10.1023/A:1015021603681 sideral 51908 ART-2002-51908 eng Serrano, Trinidad (orcid)0000-0002-7119-2244 Bleeding duodenal ulcer and association with polymorphism of endothelial constitutive nitric oxide synthase gene. 2002 Nitric oxide (NO) exerts both protective and proinflammatory actions in the gastrointestinal tract. Enhanced gastric NO synthase (NOS) activity has been shown in duodenal ulcer patients. Recently, intron-4 polymorphism of the endothelial constitutive (ec) NOS gene has been associated with some pathological conditions. Our aim was to determine the genotype and allele frequencies of the ecNOS4 polymorphism in peptic ulcer patients. The distribution of the polymorphism ecNOS4a/b was studied in 188 ulcer patients and 120 healthy controls, from genomic DNA. Genotypes ab, bb, and aa and allele frequency were similar in both peptic ulcer patients and controls, and no differences were found when patients and controls were analyzed according to the presence of several etiological factors. However, alelle “a” carrier status was associated with decreased risk of bleeding in duodenal ulcer patients (OR 0.49; 95% CI 0.25– 0.95; P 0.03). In conclusion, this ecNOS4 polymorphism gene could be related to susceptibility of duodenal ulcer patients to bleeding. KEY WORDS: endothelial nitric oxide synthase; DNA polymorphism; peptic ulcer. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 1.438 2002 GASTROENTEROLOGY & HEPATOLOGY 27 / 45 = 0.6 2002 Q3 T2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Piazuelo, Elena (orcid)0000-0001-5813-3445 Benito, Rafael Universidad de Zaragoza (orcid)0000-0001-5134-1006 Santolaria, Santos Lanas, Angel Universidad de Zaragoza (orcid)0000-0001-5932-2889 1008 630 Universidad de Zaragoza Dpto. Microb.Med.Pr.,Sal.Públ. Área Microbiología 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 47, 5 (2002), 996-1000 Dig. dis. sci. Digestive Diseases and Sciences 0163-2116 1233697 http://zaguan.unizar.es/record/130271/files/texto_completo.pdf Versión publicada 2456301 http://zaguan.unizar.es/record/130271/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130271 articulos driver 2024-01-24-14:58:47 ARTICLE