000130272 001__ 130272
000130272 005__ 20240124152850.0
000130272 0247_ $$2doi$$a10.1016/j.clinbiochem.2015.12.017
000130272 0248_ $$2sideral$$a94337
000130272 037__ $$aART-2016-94337
000130272 041__ $$aeng
000130272 100__ $$0(orcid)0000-0002-6361-9228$$aAndrés-Otero, María Jesús
000130272 245__ $$aMultiple approaches to assess fourteen non-invasive serum indexes for the diagnosis of liver fibrosis in chronic hepatitis C patients.
000130272 260__ $$c2016
000130272 5203_ $$aBackground: The aim of this study was to compare fourteen non-invasive indexes/scores: AAR, APRI, Fibroindex, MODEL3, Forns index, FIB4, GUCI, FI, FCI, Pohl score, AP index, CDS, HGM-1 and HGM-2, in order to diagnose the hepatic fibrosis stage in a survey of patients with chronic hepatitis C.
Methods. 84 patients with chronic hepatitis C were studied. Liver fibrosis was staged according to the Scheuer scoring system. The diagnostic accuracy of these indexes/scores was evaluated by AUROC, contingency tables and logistic regression analysis.
Results: The best AUROCs (> 0.9) to discriminate cirrhosis (F = 4), were observed for CDS, FI, AAR, MODEL3, FIB4, HGM-2 and FCI. To discriminate at least advance fibrosis (F = 3), the best AUROCs (> 0.89) were for CDS, FI, FIB4, HGM2-2, MODEL3 and FCI. To discriminate at least significant fibrosis (F = 2), the best AUROCs (> 0.8) were for FIB4, GUCI, APRI, FI, Forns index, HGM-2 and FCI. Contingency tables and logistic regression analysis supported the results obtained by AUROC.
Conclusions: This study compares the diagnostic performance of fourteen indexes for the diagnosis of liver fibrosis stage in the same group of CHC patients. These results allow the selection of the best indexes for further studies in larger populations, in order to build diagnostic algorithms as an alternative to liver biopsy for fibrosis staging in patients with chronic HCV infection. These algorithms would allow to take therapeutical decisions and the continuous follow-up of hepatic fibrosis in these patients.
000130272 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130272 590__ $$a2.434$$b2016
000130272 591__ $$aMEDICAL LABORATORY TECHNOLOGY$$b11 / 30 = 0.367$$c2016$$dQ2$$eT2
000130272 592__ $$a0.942$$b2016
000130272 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000130272 593__ $$aClinical Biochemistry$$c2016$$dQ2
000130272 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130272 700__ $$0(orcid)0000-0002-1204-4356$$aDe-Blas-Giral, Ignacio$$uUniversidad de Zaragoza
000130272 700__ $$0(orcid)0000-0002-7213-7095$$aPuente-Lanzarote, Juan José
000130272 700__ $$0(orcid)0000-0002-7119-2244$$aSerrano-Aulló, Trinidad$$uUniversidad de Zaragoza
000130272 700__ $$0(orcid)0000-0002-9617-3744$$aMorandeira, María José$$uUniversidad de Zaragoza
000130272 700__ $$0(orcid)0000-0003-4672-8083$$aLorente, Sara$$uUniversidad de Zaragoza
000130272 700__ $$0(orcid)0000-0001-9578-6525$$aLou-Bonafonte, José Manuel$$uUniversidad de Zaragoza
000130272 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000130272 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000130272 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000130272 7102_ $$11000$$2020$$aUniversidad de Zaragoza$$bDpto. Anat.Pat.Med.Leg.For.To.$$cArea Anatomía Patológica
000130272 773__ $$g49, 7-8 (2016), 560-565$$pClin. biochem.$$tCLINICAL BIOCHEMISTRY$$x0009-9120
000130272 8564_ $$s392836$$uhttps://zaguan.unizar.es/record/130272/files/texto_completo.pdf$$yVersión publicada
000130272 8564_ $$s2655909$$uhttps://zaguan.unizar.es/record/130272/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130272 909CO $$ooai:zaguan.unizar.es:130272$$particulos$$pdriver
000130272 951__ $$a2024-01-24-14:58:50
000130272 980__ $$aARTICLE