130272 20240124152850.0 doi 10.1016/j.clinbiochem.2015.12.017 sideral 94337 ART-2016-94337 eng Andrés-Otero, María Jesús (orcid)0000-0002-6361-9228 Multiple approaches to assess fourteen non-invasive serum indexes for the diagnosis of liver fibrosis in chronic hepatitis C patients. 2016 Background: The aim of this study was to compare fourteen non-invasive indexes/scores: AAR, APRI, Fibroindex, MODEL3, Forns index, FIB4, GUCI, FI, FCI, Pohl score, AP index, CDS, HGM-1 and HGM-2, in order to diagnose the hepatic fibrosis stage in a survey of patients with chronic hepatitis C. Methods. 84 patients with chronic hepatitis C were studied. Liver fibrosis was staged according to the Scheuer scoring system. The diagnostic accuracy of these indexes/scores was evaluated by AUROC, contingency tables and logistic regression analysis. Results: The best AUROCs (> 0.9) to discriminate cirrhosis (F = 4), were observed for CDS, FI, AAR, MODEL3, FIB4, HGM-2 and FCI. To discriminate at least advance fibrosis (F = 3), the best AUROCs (> 0.89) were for CDS, FI, FIB4, HGM2-2, MODEL3 and FCI. To discriminate at least significant fibrosis (F = 2), the best AUROCs (> 0.8) were for FIB4, GUCI, APRI, FI, Forns index, HGM-2 and FCI. Contingency tables and logistic regression analysis supported the results obtained by AUROC. Conclusions: This study compares the diagnostic performance of fourteen indexes for the diagnosis of liver fibrosis stage in the same group of CHC patients. These results allow the selection of the best indexes for further studies in larger populations, in order to build diagnostic algorithms as an alternative to liver biopsy for fibrosis staging in patients with chronic HCV infection. These algorithms would allow to take therapeutical decisions and the continuous follow-up of hepatic fibrosis in these patients. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 2.434 2016 MEDICAL LABORATORY TECHNOLOGY 11 / 30 = 0.367 2016 Q2 T2 0.942 2016 Medicine (miscellaneous) 2016 Q1 Clinical Biochemistry 2016 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion De-Blas-Giral, Ignacio Universidad de Zaragoza (orcid)0000-0002-1204-4356 Puente-Lanzarote, Juan José (orcid)0000-0002-7213-7095 Serrano-Aulló, Trinidad Universidad de Zaragoza (orcid)0000-0002-7119-2244 Morandeira, María José Universidad de Zaragoza (orcid)0000-0002-9617-3744 Lorente, Sara Universidad de Zaragoza (orcid)0000-0003-4672-8083 Lou-Bonafonte, José Manuel Universidad de Zaragoza (orcid)0000-0001-9578-6525 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 1005 410 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Fisiología 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1000 020 Universidad de Zaragoza Dpto. Anat.Pat.Med.Leg.For.To. Area Anatomía Patológica 49, 7-8 (2016), 560-565 Clin. biochem. CLINICAL BIOCHEMISTRY 0009-9120 392836 http://zaguan.unizar.es/record/130272/files/texto_completo.pdf Versión publicada 2655909 http://zaguan.unizar.es/record/130272/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130272 articulos driver 2024-01-24-14:58:50 ARTICLE