000130278 001__ 130278
000130278 005__ 20240124152850.0
000130278 0247_ $$2doi$$a10.1002/hep.28321
000130278 0248_ $$2sideral$$a93618
000130278 037__ $$aART-2016-93618
000130278 041__ $$aeng
000130278 100__ $$aAgüero, F.
000130278 245__ $$aHuman immunodeficiency virus infection does not worsen prognosis of liver transplantation for hepatocellular carcinoma
000130278 260__ $$c2016
000130278 5203_ $$aThe impact of human immunodeficiency virus (HIV) infection on patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) is uncertain. This study aimed to assess the outcome of a prospective Spanish nationwide cohort of HIV-infected patients undergoing LT for HCC (2002-2014). These patients were matched (age, gender, year of LT, center, and hepatitis C virus (HCV) or hepatitis B virus infection) with non-HIV-infected controls (1:3 ratio). Patients with incidental HCC were excluded. Seventy-four HIV-infected patients and 222 non-HIV-infected patients were included. All patients had cirrhosis, mostly due to HCV infection (92%). HIV-infected patients were younger (47 versus 51 years) and had undetectable HCV RNA at LT (19% versus 9%) more frequently than non-HIV-infected patients. No significant differences were detected between HIV-infected and non-HIV-infected recipients in the radiological characteristics of HCC at enlisting or in the histopathological findings for HCC in the explanted liver. Survival at 1, 3, and 5 years for HIV-infected versus non-HIV-infected patients was 88% versus 90%, 78% versus 78%, and 67% versus 73% (P = 0.779), respectively. HCV infection (hazard ratio = 7.90, 95% confidence interval 1.07-56.82) and maximum nodule diameter >3 cm in the explanted liver (hazard ratio = 1.72, 95% confidence interval 1.02-2.89) were independently associated with mortality in the whole series. HCC recurred in 12 HIV-infected patients (16%) and 32 non-HIV-infected patients (14%), with a probability of 4% versus 5% at 1 year, 18% versus 12% at 3 years, and 20% versus 19% at 5 years (P = 0.904). Microscopic vascular invasion (hazard ratio = 3.40, 95% confidence interval 1.34-8.64) was the only factor independently associated with HCC recurrence. Conclusions: HIV infection had no impact on recurrence of HCC or survival after LT. Our results support the indication of LT in HIV-infected patients with HCC.
000130278 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130278 590__ $$a13.246$$b2016
000130278 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b4 / 79 = 0.051$$c2016$$dQ1$$eT1
000130278 592__ $$a5.229$$b2016
000130278 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000130278 593__ $$aHepatology$$c2016$$dQ1
000130278 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130278 700__ $$aForner, A.
000130278 700__ $$aManzardo, C.
000130278 700__ $$aValdivieso, A.
000130278 700__ $$aBlanes, M.
000130278 700__ $$aBarcena, R.
000130278 700__ $$aRafecas, A.
000130278 700__ $$aCastells, L.
000130278 700__ $$aAbradelo, M.
000130278 700__ $$aTorre-Cisneros, J.
000130278 700__ $$aGonzalez-Dieguez, L.
000130278 700__ $$aSalcedo, M.
000130278 700__ $$0(orcid)0000-0002-7119-2244$$aSerrano, T.$$uUniversidad de Zaragoza
000130278 700__ $$aJimenez-Perez, M.
000130278 700__ $$aHerrero, J. I.
000130278 700__ $$aGastaca, M.
000130278 700__ $$aAguilera, V.
000130278 700__ $$aFabregat, J.
000130278 700__ $$adel Campo, S.
000130278 700__ $$aBilbao, I.
000130278 700__ $$aRomero, C. J.
000130278 700__ $$aMoreno, A.
000130278 700__ $$aRimola, A.
000130278 700__ $$aMiro, J. M.
000130278 700__ $$aMiro, J. M.
000130278 700__ $$aAguero, F.
000130278 700__ $$aBlanch, J.
000130278 700__ $$aBrunet, M.
000130278 700__ $$aCalatayud, D.
000130278 700__ $$aCervera, C.
000130278 700__ $$aCrespo, G.
000130278 700__ $$ade Lazzari, E.
000130278 700__ $$aFondevila, C.
000130278 700__ $$aForner, A.
000130278 700__ $$aFuster, J.
000130278 700__ $$aForns, X.
000130278 700__ $$aGarcía-Valdecasas, J. C.
000130278 700__ $$aGil, A.
000130278 700__ $$aGatell, J. M.
000130278 700__ $$aLaguno, M.
000130278 700__ $$aLligoña, A.
000130278 700__ $$aLondoño, M. C.
000130278 700__ $$aMallolas, J.
000130278 700__ $$aManzardo, C.
000130278 700__ $$aMonrás, M.
000130278 700__ $$aMoreno, A.
000130278 700__ $$aMurillas, J.
000130278 700__ $$aNavasa, M.
000130278 700__ $$aParedes, D.
000130278 700__ $$aPérez, I.
000130278 700__ $$aTural, C.
000130278 700__ $$aTuset, M.
000130278 700__ $$aRimola, A.
000130278 700__ $$aTorre-Cisneros J.
000130278 700__ $$aBarrera, P.
000130278 700__ $$aBriceño, J.
000130278 700__ $$aCaston, J. J.
000130278 700__ $$aCostan, G.
000130278 700__ $$ade, la Mata
000130278 700__ $$aLara, R.
000130278 700__ $$aLópez- Cillero, P.
000130278 700__ $$aMontero, J. L.
000130278 700__ $$aRivero, A.
000130278 700__ $$aRufian, S.
000130278 700__ $$aSuárez, F.
000130278 700__ $$aCastro, M. A.
000130278 700__ $$aLópez, S.
000130278 700__ $$aPedreira, J. D.
000130278 700__ $$aVázquez, P.
000130278 700__ $$aAntela, A.
000130278 700__ $$aLosada, E.
000130278 700__ $$aMolina, E.
000130278 700__ $$aOtero, E.
000130278 700__ $$aVaro, E.
000130278 700__ $$aSerrano, T.
000130278 700__ $$0(orcid)0000-0001-6033-2216$$aAraiz, J. J.$$uUniversidad de Zaragoza
000130278 700__ $$aBarrao, E.
000130278 700__ $$aLarraga, J.
000130278 700__ $$0(orcid)0000-0002-5321-418X$$aLetona, S.$$uUniversidad de Zaragoza
000130278 700__ $$aLozano, R.
000130278 700__ $$aLuque, P.
000130278 700__ $$aNavarro, A.
000130278 700__ $$aSanjoaquín, I.
000130278 700__ $$aTejero, E.
000130278 700__ $$aSalcedo, M.
000130278 700__ $$aBañares, R.
000130278 700__ $$aBerenguer, J.
000130278 700__ $$aClemente, G.
000130278 700__ $$aCosín, J.
000130278 700__ $$aFerreiroa, J. P.
000130278 700__ $$aGarcía-Sabrido, J. L.
000130278 700__ $$aGutiérrez, I.
000130278 700__ $$aLópez, J. C.
000130278 700__ $$aMiralles, P.
000130278 700__ $$aRamírez, M.
000130278 700__ $$aRincón, D.
000130278 700__ $$aSánchez, M.
000130278 700__ $$aJiménez, M.
000130278 700__ $$ade, la Cruz
000130278 700__ $$aFernández, J. L.
000130278 700__ $$aLozano, J. M.
000130278 700__ $$aSantoyo, J.
000130278 700__ $$aRodrigo, J. M.
000130278 700__ $$aSuárez, M. A.
000130278 700__ $$aRodríguez, M.
000130278 700__ $$aAlonso, M. P.
000130278 700__ $$aAsensi, V.
000130278 700__ $$aGonzález-Diéguez, M. L.
000130278 700__ $$aGonzález-Pinto, I.
000130278 700__ $$aRafecas, A.
000130278 700__ $$aBaliellas, C.
000130278 700__ $$aCarratalá, J.
000130278 700__ $$aFabregat, J.
000130278 700__ $$aFernández, N.
000130278 700__ $$aJorba, R.
000130278 700__ $$aLladó, L.
000130278 700__ $$aXiol, X.
000130278 700__ $$aMontejo, M.
000130278 700__ $$aBustamante, J.
000130278 700__ $$aFernández, J. R.
000130278 700__ $$aGastaca, M.
000130278 700__ $$aGonzález, J.
000130278 700__ $$aMontejo, E.
000130278 700__ $$aOrtiz, de Urbina
000130278 700__ $$aRuiz, P.
000130278 700__ $$aSuárez, M. J.
000130278 700__ $$aTestillano, M.
000130278 700__ $$aValdivieso, A.
000130278 700__ $$aVentoso, A.
000130278 700__ $$aAbradelo, M.
000130278 700__ $$aCalvo, J.
000130278 700__ $$aCosta, J. R.
000130278 700__ $$aGarcía-Sesma, A.
000130278 700__ $$aJiménez, C.
000130278 700__ $$aManrique, A.
000130278 700__ $$aMeneu, J. C.
000130278 700__ $$aMoreno, E.
000130278 700__ $$aMoreno, V.
000130278 700__ $$aOlivares, S. P.
000130278 700__ $$aPulido, F.
000130278 700__ $$aRubio, R.
000130278 700__ $$aBlanes, M.
000130278 700__ $$aAguilera, V.
000130278 700__ $$aBerenguer, M.
000130278 700__ $$aLópez, J.
000130278 700__ $$aLópez, R.
000130278 700__ $$aPrieto, M.
000130278 700__ $$aFariñas, M. C.
000130278 700__ $$aCasafont, F.
000130278 700__ $$aEchevarria, S.
000130278 700__ $$aFábrega, E.
000130278 700__ $$aGomez-Fleitas, M.
000130278 700__ $$aGutiérrez-Cuadra, M.
000130278 700__ $$aHerrera-Noreña, J. L.
000130278 700__ $$aMoreno, S.
000130278 700__ $$aBarcena, R.
000130278 700__ $$adel Campo, S.
000130278 700__ $$aFortún, J.
000130278 700__ $$aMoreno, A. M.
000130278 700__ $$aMartín- Dávila, P.
000130278 700__ $$aCastells, L. l.
000130278 700__ $$aBilbao, I.
000130278 700__ $$aCampos-Varela, I.
000130278 700__ $$aCharco, R.
000130278 700__ $$aEsteban, J. I.
000130278 700__ $$aGavaldá, J.
000130278 700__ $$aLen, O.
000130278 700__ $$aPahissa, A.
000130278 700__ $$aRibera, E.
000130278 700__ $$aVargas, V.
000130278 700__ $$aPons, J. A.
000130278 700__ $$aCordero, E.
000130278 700__ $$aBernal, C.
000130278 700__ $$aCisneros, J. M.
000130278 700__ $$aGómez, M. A.
000130278 700__ $$aPascasio, J. M.
000130278 700__ $$aRodríguez, M. J.
000130278 700__ $$aSayago, M.
000130278 700__ $$aSousa, J. M.
000130278 700__ $$aSuárez, G.
000130278 700__ $$aGonzález-García, J.
000130278 700__ $$aMuffak, K.
000130278 700__ $$aFerrón, A.
000130278 700__ $$aGarrote, D.
000130278 700__ $$aEspinosa, M.
000130278 700__ $$aSánchez- Antolín, G.
000130278 700__ $$aGarcia, F.
000130278 700__ $$aBarrera, A.
000130278 700__ $$aBachiller, P.
000130278 700__ $$aConde, R.
000130278 700__ $$aNoblejas, A.
000130278 700__ $$aEscamilla, N.
000130278 700__ $$aPérez, I.
000130278 700__ $$aHayek, M.
000130278 700__ $$aLinares, M.
000130278 700__ $$aArencibia, A.
000130278 700__ $$aMinguelez, M.
000130278 700__ $$aAznar, E.
000130278 700__ $$aEsteban, H.
000130278 700__ $$aMoyano, B.
000130278 700__ $$ade, la Rosa
000130278 700__ $$aGarrido, G.
000130278 700__ $$aMahillo, B.
000130278 700__ $$aMatesanz, R.
000130278 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000130278 773__ $$g63, 2 (2016), 488-498$$pHepatology$$tHEPATOLOGY$$x0270-9139
000130278 8564_ $$s449409$$uhttps://zaguan.unizar.es/record/130278/files/texto_completo.pdf$$yVersión publicada
000130278 8564_ $$s2740668$$uhttps://zaguan.unizar.es/record/130278/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130278 909CO $$ooai:zaguan.unizar.es:130278$$particulos$$pdriver
000130278 951__ $$a2024-01-24-14:59:22
000130278 980__ $$aARTICLE