130284 20240124152850.0 doi 10.1016/j.atherosclerosis.2017.06.009 sideral 99664 ART-2017-99664 eng Bea, A.M. Effect of intensive LDL cholesterol lowering with PCSK9 monoclonal antibodies on tendon xanthoma regression in familial hypercholesterolemia 2017 Background and aims: The effect of LDLc lowering with PCSK9 antibodies on tendon xanthomas (TX) is unknown. Methods: TX was measured in 24 heterozygous familial hypercholesterolemia (HeFH) cases and in 24 HeFH controls with or without PCSK9 inhibitors for at least one year. Results: Exposure to PCSK9 inhibitors in cases was 2.96 ± 1.33 years. LDLc decreased 80.8 ± 7.66% in cases and 56.9 ± 11.1% in controls. There was a decrease in maximum (-5.03%) and mean (-5.32%) TX in cases but not in controls (+3.97%, +3.16, respectively, p = 0.01). PCSK9 inhibitor treatment was independently associated with TX reduction. Conclusion: Addition of a PCSK9 inhibitor to statin and ezetimibe resulted in a greater decrease in LDLc and TX after 3 years of treatment. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/ISCIII/FIS/IIS16-0114 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PIE16-00022 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-01983 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 4.467 2017 PERIPHERAL VASCULAR DISEASE 9 / 65 = 0.138 2017 Q1 T1 CARDIAC & CARDIOVASCULAR SYSTEMS 34 / 128 = 0.266 2017 Q2 T1 1.967 2017 Cardiology and Cardiovascular Medicine 2017 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Perez-Calahorra, S. (orcid)0000-0002-1894-1621 Marco-Benedi, V. Lamiquiz-Moneo, I. (orcid)0000-0002-9647-0108 Jarauta, E. Universidad de Zaragoza (orcid)0000-0001-9142-0737 Mateo Gallego, R. Universidad de Zaragoza (orcid)0000-0001-6650-8294 Civeira, F. Universidad de Zaragoza (orcid)0000-0001-7043-0952 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 263 (2017), 92-96 Atherosclerosis Atherosclerosis 0021-9150 267304 http://zaguan.unizar.es/record/130284/files/texto_completo.pdf Postprint 1148710 http://zaguan.unizar.es/record/130284/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:130284 articulos driver 2024-01-24-14:59:51 ARTICLE