000130291 001__ 130291
000130291 005__ 20240124152850.0
000130291 0247_ $$2doi$$a10.2741/e215
000130291 0248_ $$2sideral$$a76927
000130291 037__ $$aART-2011-76927
000130291 041__ $$aeng
000130291 100__ $$0(orcid)0000-0002-8100-5596$$aMartinez-Beamonte, R.
000130291 245__ $$aPostprandial transcriptome associated with virgin olive oil intake in rat liver.
000130291 260__ $$c2011
000130291 5203_ $$aLiver has been proposed as a gatekeeper that regulates postprandial lipemia and a potential target for regulation by acute intake of virgin olive oil. To characterize the hepatic gene expression response to a fat gavage, male rats were fed a bolus of 5 ml of extra-virgin olive oil and the hepatic mRNA expression analyzed 4 hours later using DNA microarrays. To provide an initial screening of candidate genes, only twenty one with remarkably modified expression between both conditions (signal log2 ratio > 2.5 or < -2.5) were considered and confirmed by quantitative real time PCR. Those that presented biological significance were also analyzed 8 hours after the experimental approach. Hepatic A2m Slc13a5 and Nrep mRNA expressions were found significantly changed in both studied conditions and showed the highest significant associations with postprandial plasma triglycerides and lack of association with basal triglyceridemia. These results highlight new gene regulation in liver by postprandial triglyceridemia and will help to understand the complex human pathology providing the involvement of hepatic proteins and new strategies to cope with postprandial metabolism.
000130291 536__ $$9info:eu-repo/grantAgreement/ES/CICYT/SAF2007-60173$$9info:eu-repo/grantAgreement/ES/DGA-FSE/B69
000130291 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130291 590__ $$a3.52$$b2011
000130291 591__ $$aCELL BIOLOGY$$b84 / 179 = 0.469$$c2011$$dQ2$$eT2
000130291 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b104 / 287 = 0.362$$c2011$$dQ2$$eT2
000130291 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130291 700__ $$0(orcid)0000-0002-0108-1004$$aNavarro, M.A.$$uUniversidad de Zaragoza
000130291 700__ $$0(orcid)0000-0001-6627-298X$$aGuillén, N.$$uUniversidad de Zaragoza
000130291 700__ $$aAcin, S.
000130291 700__ $$0(orcid)0000-0003-1197-4276$$aArnal, C.$$uUniversidad de Zaragoza
000130291 700__ $$aGuzmán, M.A.
000130291 700__ $$0(orcid)0000-0002-8251-8457$$aOsada J.$$uUniversidad de Zaragoza
000130291 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000130291 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000130291 7102_ $$11000$$2807$$aUniversidad de Zaragoza$$bDpto. Anat.Pat.Med.Leg.For.To.$$cArea Toxicología
000130291 773__ $$g3, 1 (2011), 11-21$$pFront. biosci.$$tFRONTIERS IN BIOSCIENCE$$x1093-9946
000130291 8564_ $$s319555$$uhttps://zaguan.unizar.es/record/130291/files/texto_completo.pdf$$yVersión publicada
000130291 8564_ $$s1892340$$uhttps://zaguan.unizar.es/record/130291/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130291 909CO $$ooai:zaguan.unizar.es:130291$$particulos$$pdriver
000130291 951__ $$a2024-01-24-15:00:31
000130291 980__ $$aARTICLE