130291 20260213183046.0 doi 10.2741/e215 sideral 76927 ART-2011-76927 eng Martinez-Beamonte, R. (orcid)0000-0002-8100-5596 Postprandial transcriptome associated with virgin olive oil intake in rat liver 2011 Liver has been proposed as a gatekeeper that regulates postprandial lipemia and a potential target for regulation by acute intake of virgin olive oil. To characterize the hepatic gene expression response to a fat gavage, male rats were fed a bolus of 5 ml of extra-virgin olive oil and the hepatic mRNA expression analyzed 4 hours later using DNA microarrays. To provide an initial screening of candidate genes, only twenty one with remarkably modified expression between both conditions (signal log2 ratio > 2.5 or < -2.5) were considered and confirmed by quantitative real time PCR. Those that presented biological significance were also analyzed 8 hours after the experimental approach. Hepatic A2m Slc13a5 and Nrep mRNA expressions were found significantly changed in both studied conditions and showed the highest significant associations with postprandial plasma triglycerides and lack of association with basal triglyceridemia. These results highlight new gene regulation in liver by postprandial triglyceridemia and will help to understand the complex human pathology providing the involvement of hepatic proteins and new strategies to cope with postprandial metabolism. info:eu-repo/grantAgreement/ES/CICYT/SAF2007-60173 info:eu-repo/grantAgreement/ES/DGA-FSE/B69 info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.52 2011 CELL BIOLOGY 84 / 179 = 0.469 2011 Q2 T2 BIOCHEMISTRY & MOLECULAR BIOLOGY 104 / 287 = 0.362 2011 Q2 T2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Navarro, M.A. Universidad de Zaragoza (orcid)0000-0002-0108-1004 Guillén, N. Universidad de Zaragoza (orcid)0000-0001-6627-298X Acin, S. Arnal, C. Universidad de Zaragoza (orcid)0000-0003-1197-4276 Guzmán, M.A. Osada J. Universidad de Zaragoza (orcid)0000-0002-8251-8457 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 1000 807 Universidad de Zaragoza Dpto. Anat.Pat.Med.Leg.For.To. Area Toxicología 3, 1 (2011), 11-21 Front. biosci. (Elite ed.) Frontiers in bioscience (Elite edition) 1945-0494 319555 http://zaguan.unizar.es/record/130291/files/texto_completo.pdf Versión publicada 1892340 http://zaguan.unizar.es/record/130291/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130291 articulos driver 2026-02-13-18:30:18 ARTICLE