000130295 001__ 130295 000130295 005__ 20240130142253.0 000130295 0247_ $$2doi$$a10.1016/j.jveb.2012.01.005 000130295 0248_ $$2sideral$$a79024 000130295 037__ $$aART-2012-79024 000130295 041__ $$aeng 000130295 100__ $$aLeón, M. 000130295 245__ $$aAssessment of serotonin in serum, plasma, and platelets of aggressive dogs 000130295 260__ $$c2012 000130295 5060_ $$aAccess copy available to the general public$$fUnrestricted 000130295 5203_ $$aCanine aggression is the most common reason for the referral of dogs to behavior practices. In addition, dog bites represent an important problem for public health and animal welfare. The serotonergic system is believed to play an important role in modulating aggression. The aim of the present study was (1) to assess the suitability of different types of blood samples for measuring circulating serotonin in canine clinical studies, and (2) to investigate the relationship between the serotonergic system and canine aggression. The assessment of serotonin was simultaneously carried out in serum, plasma, and platelets of 28 aggressive and 10 nonaggressive dogs with an enzyme immunoassay technique. The mean serotonin concentration in aggressive dogs was significantly lower than in nonaggressive dogs in all the assayed samples. These findings suggest an inverse relationship between the activity of the serotonergic system and canine aggression. Considering the simplicity of the methodology, the authors propose sampling serum as the most suitable method for measuring circulating serotonin in dogs. 000130295 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000130295 590__ $$a1.653$$b2012 000130295 591__ $$aVETERINARY SCIENCES$$b27 / 142 = 0.19$$c2012$$dQ1$$eT1 000130295 591__ $$aBEHAVIORAL SCIENCES$$b40 / 49 = 0.816$$c2012$$dQ4$$eT3 000130295 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000130295 700__ $$0(orcid)0000-0003-1728-900X$$aRosado, B.$$uUniversidad de Zaragoza 000130295 700__ $$0(orcid)0000-0001-5084-6555$$aGarcía-Belenguer, S.$$uUniversidad de Zaragoza 000130295 700__ $$aChacón, G. 000130295 700__ $$0(orcid)0000-0001-8398-5463$$aVillegas, A.$$uUniversidad de Zaragoza 000130295 700__ $$0(orcid)0000-0002-1581-3085$$aPalacio, J.$$uUniversidad de Zaragoza 000130295 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal 000130295 773__ $$g7, 6 (2012), 348-352$$pJournal of Veterinary Behavior-Clinical Applications and Research$$tJournal of Veterinary Behavior$$x1558-7878 000130295 8564_ $$s195122$$uhttps://zaguan.unizar.es/record/130295/files/texto_completo.pdf$$yPostprint 000130295 8564_ $$s781749$$uhttps://zaguan.unizar.es/record/130295/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000130295 909CO $$ooai:zaguan.unizar.es:130295$$particulos$$pdriver 000130295 951__ $$a2024-01-30-14:18:10 000130295 980__ $$aARTICLE