000130299 001__ 130299
000130299 005__ 20240130142253.0
000130299 0247_ $$2doi$$a10.1016/j.applanim.2010.01.009
000130299 0248_ $$2sideral$$a72158
000130299 037__ $$aART-2010-72158
000130299 041__ $$aeng
000130299 100__ $$0(orcid)0000-0003-1728-900X$$aRosado, B.$$uUniversidad de Zaragoza
000130299 245__ $$aBlood concentrations of serotonin, cortisol and dehydroepiandrosterone in aggressive dogs
000130299 260__ $$c2010
000130299 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130299 5203_ $$aCanine aggression directed towards people is the most frequent reason for referral to behaviour practices. In order to provide new and improved diagnostic and therapeutic approaches for this problem, it is necessary to make an in-depth investigation of the biological basis of aggression in this species. The serotonergic system and the hypothalamic–pituitary–adrenal (HPA) axis are believed to play an important role in controlling aggression. The aim of the present study was to investigate both systems in aggressive (n = 80) and control non-aggressive (n = 19) dogs through the assessment of peripheral parameters, namely serum serotonin (5-HT), and plasma cortisol and dehydroepiandrosterone (DHEA). Moreover, the effect of the category of aggression and gender was investigated. Aggressive dogs showed significantly lower serum concentrations of 5-HT than non-aggressive dogs (278.5 ng/ml vs. 387.4 ng/ml, P < 0.01). The lowest 5-HT concentrations were found in the group of dogs showing defensive forms of aggression. Aggressive animals showed significantly higher plasma concentrations of cortisol than non-aggressive dogs (21.4 ng/ml vs. 10.6 ng/ml, P = 0.05). Finally, males as a whole showed significantly higher plasma concentrations of DHEA and DHEA/cortisol ratio values than did females (DHEA: 90.9 ng/ml vs. 29.8 ng/ml, P < 0.05; ratio: 9.5 vs. 3.8, P < 0.01). The present results suggest that aggressive dogs might differ from non-aggressive dogs in the activities of the serotonergic system and the HPA axis.
000130299 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000130299 590__ $$a1.555$$b2010
000130299 591__ $$aAGRICULTURE, DAIRY & ANIMAL SCIENCE$$b13 / 55 = 0.236$$c2010$$dQ1$$eT1
000130299 591__ $$aVETERINARY SCIENCES$$b29 / 144 = 0.201$$c2010$$dQ1$$eT1
000130299 591__ $$aBEHAVIORAL SCIENCES$$b38 / 48 = 0.792$$c2010$$dQ4$$eT3
000130299 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000130299 700__ $$0(orcid)0000-0001-5084-6555$$aGarcía-Belenguer, S.$$uUniversidad de Zaragoza
000130299 700__ $$aLeón, M.
000130299 700__ $$aChacón, G.
000130299 700__ $$0(orcid)0000-0001-8398-5463$$aVillegas, A.
000130299 700__ $$0(orcid)0000-0002-1581-3085$$aPalacio, J.$$uUniversidad de Zaragoza
000130299 7102_ $$11001$$2X$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cProy. investigación DDA
000130299 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000130299 773__ $$g123, 3-4 (2010), 124-130$$pAppl. anim. behav. sci.$$tApplied Animal Behaviour Science$$x0168-1591
000130299 8564_ $$s236371$$uhttps://zaguan.unizar.es/record/130299/files/texto_completo.pdf$$yPostprint
000130299 8564_ $$s795169$$uhttps://zaguan.unizar.es/record/130299/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000130299 909CO $$ooai:zaguan.unizar.es:130299$$particulos$$pdriver
000130299 951__ $$a2024-01-30-14:18:26
000130299 980__ $$aARTICLE